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首页> 外文期刊>EMBO Journal >Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation
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Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation

机译：武藏调节mRNA的时间顺序翻译在非洲爪蟾蜍卵母细胞成熟

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摘要

A strict temporal order of maternal mRNA translation is essential for meiotic cell cycle progression in oocytes of the frog Xenopus laevis. The molecular mechanisms controlling the ordered pattern of mRNA translational activation have not been elucidated. We report a novel role for the neural stem cell regulatory protein, Musashi, in controlling the translational activation of the mRNA encoding the Mos proto-oncogene during meiotic cell cycle progression. We demonstrate that Musashi interacts specifically with the polyadenylation response element in the 30 untranslated region of the Mos mRNA and that this interaction is necessary for early Mos mRNA translational activation. A dominant inhibitory form of Musashi blocks maternal mRNA cytoplasmic polyadenylation and meiotic cell cycle progression. Our data suggest that Musashi is a target of the initiating progesterone signaling pathway and reveal that late cytoplasmic polyadenylation element-directed mRNA translation requires early, Musashi-dependent mRNA translation. These findings indicate that Musashi function is necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cycle progression.
机译：一个严格的时间顺序的孕产妇mRNA翻译对减数分裂细胞周期至关重要进展青蛙非洲爪蟾蜍的卵母细胞光滑的。命令的mRNA平移激活模式尚未阐明。神经干细胞调控蛋白,武藏,在控制平动激活信使rna编码的金属氧化物半导体原癌基因在减数分裂过程中细胞周期进展。具体交互聚腺苷酸化响应元素在30翻译区Mos mRNA和交互早期Mos mRNA转化的必要条件激活。块孕产妇mRNA细胞质聚腺苷酸化减数分裂细胞周期进程。建议的武藏是一个目标启动孕激素信号通路显示,胞质聚腺苷酸化element-directed mRNA翻译需要早期,Musashi-dependent信使核糖核酸的翻译。结果表明,武藏函数有必要建立的时间顺序孕产妇mRNA翻译在非洲爪蟾蜍减数分裂细胞周期进程。

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