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首页> 外文期刊>Catalysis science & technology >The first one-pot metathesis-hydroformylation procedure: a straight synthesis of 2-arylpropanals from renewable 1-propenylbenzenes
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The first one-pot metathesis-hydroformylation procedure: a straight synthesis of 2-arylpropanals from renewable 1-propenylbenzenes

机译：第一个锅metathesis-hydroformylation过程:直接合成2-arylpropanals来自可再生1-propenylbenzenes

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Hydroformylation is a consolidated synthetic tool in the chemical industry, both in commodity and in the fine chemicals industry. Olefin metathesis has been largely employed in the petrochemical sector, and, more recently, in the synthesis of specialty chemicals. Although these reactions may be involved in the same synthetic route for various industrial chemicals, to the best of our knowledge, they have never been combined in a one-pot procedure. As a proof of concept, we have demonstrated in the present work that the ruthenium-catalyzed ethenolysis of renewable 1-propenylbenzenes followed by the rhodium-catalyzed hydroformylation of functionalized styrenes formed in the first step could be done in one pot. The integration of these reactions was not straightforward once the catalyst of the first step interfered with the catalyst of the second step. Under optimized conditions, it was possible to synthesize 2-arylpropanals, a class of compounds valuable as synthetic intermediates to access non-steroidal anti-inflammatory drugs, in overall yields of 85-90%, at low catalyst loadings.
机译：氢甲酰化反应是一个综合合成工具在化学工业中,大宗商品和在精细化工行业。一直主要从事石化部门,最近,合成的专业的化学物质。参与相同的合成路线各种化工原料,最好的我们知识,他们从未结合锅的过程。在目前的工作ruthenium-catalyzed ethenolysis可再生1-propenylbenzenes紧随其后的是rhodium-catalyzed加氢甲酰化的功能化苯乙烯中形成的第一步可以做在一个锅里。集成的一旦这些反应并不简单第一步干扰的催化剂第二步的催化剂。条件下,可以合成2-arylpropanals,一类化合物的价值访问非甾体合成中间体抗炎药,在整体的产量85 - 90%,催化剂在低载荷。

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