B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

Letourneux C; Rocher G; Porteu F

首页> 外文期刊>EMBO Journal >B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

【24h】

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

机译：B56-containing PP2A脱去磷酸ERK和他们活动是由早期基因IEX-1控制和ERK

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal-regulated kinase (ERK) signaling pathway but whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during mitogenic stimulation is unknown. By using both RNA interference and overexpression of PP2A B regulatory subunits, we show that B56, but not B, family members of PP2A increase ERK dephosphorylation, without affecting its activation by MEK. Induction of the early gene product and ERK substrate IEX-1 (ier3) by growth factors leads to opposite effects and reverses B56-PP2A-mediated ERK dephosphorylation. IEX-1 binds to B56 subunits and pERK independently, enhances B56 phosphorylation by ERK at a conserved Ser/Pro site in this complex and triggers dissociation from the catalytic subunit. This is the first demonstration of the involvement of B56-containing PP2A in ERK dephosphorylation and of a B56-specific cellular protein inhibitor regulating its activity in an ERK-dependent fashion. In addition, our results raise a new paradigm in ERK signaling in which ERK associated to a substrate can transphosphorylate nearby proteins.

机译：蛋白磷酸酶2 (PP2A)作用于几个在细胞外signal-regulated激酶激酶(ERK)信号通路,但是否具体的全酶脱去磷酸ERK和这个活动是否在控制促有丝分裂的刺激是未知的。RNA干扰和PP2A B超表达管理单元,我们表明,B56,但不是B,家庭成员的ERK PP2A增加脱磷酸作用,而不会影响它的由MEK激活。产品和ERK衬底IEX-1 (ier3)增长因素会导致相反的效果和逆转B56-PP2A-mediated ERK去磷酸化。结合B56独立子单元和活跃,提高B56通过ERK的磷酸化守恒的Ser /在这个复杂和专业网站从催化单元触发离解。这是第一个示范的参与B56-containing PP2A兵去磷酸化和B56-specific细胞蛋白质抑制剂调节其活动ERK-dependent时尚。提高一个新的范式在ERK信号ERK衬底可以相关联transphosphorylate附近的蛋白质。

著录项

来源
《EMBO Journal》 |2006年第4期|727-738|共12页
作者
Letourneux C; Rocher G; Porteu F;
展开▼
作者单位

Department of Hematology, Institut Cochin, INSERM U567, Paris, France.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类分子生物学;分子生物学;
关键词
Apoptosis Regulatory Proteins; Amino Acid Sequence; HeLa CellsPost-Translational Protein ProcessingCOS CellsMembrane ProteinsExtracellular Signal Regulated KinasesIER3 geneProtein Metabolism Process3T3 CellsCercopithecus aethiopsProtein Phosphatase 2Molecular Sequence DataMAP Kinase Kinase Kinase;

机译：细胞凋亡调控蛋白,氨基酸序列;海拉CellsPost-Translational蛋白质ProcessingCOS CellsMembrane ProteinsExtracellular信号调节KinasesIER3 geneProteinaethiopsProtein磷酸酶2分子序列DataMAP激酶激酶激酶;

相似文献

外文文献
中文文献
专利

1. SETBP-1/SET/PP2A/p-ERK cascade is involved in type II interleukin 1 receptor associated regorafenib resistance that is overcome by MEK inhibitors in human colorectal cancer cells [J] . Mar A. C., Chu C. H., Yang S. H., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016,第Null期

机译：SetBP-1 / Set / PP2A / PP2A / PP2A / P-ERK级联参与II型白细胞介素1受体相关的令人核苷酸抗性，由MEK抑制剂在人结肠直肠癌细胞中克服
2. Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-kB pathways and their target, IEX-1 [J] . Berengere de Laval, Patrycja Pawlikowska, Daniela Barbieri, Blood: The Journal of the American Society of Hematology . 2014,第4期

机译：血小板生成素通过特异性激活Erk和NF-kB途径及其靶标IEX-1促进造血干细胞的NHEJ DNA修复
3. Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer [J] . Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Translational Oncology . 2021,第6期

机译：ERK1 / 2和ERK5途径对乳腺癌中皮过渡的ERK1 / 2和ERK5途径的多样化和融合作用
4. Modeling and Analysis of the Cross-talk Regulators Between the AKT and ERK Signaling Pathways [C] . Yaman Arkun IFAC Symposium on Dynamics and Control of Process Systems Including Biosystems . 2020

机译：AKT和ERK信号通路之间跨谈调节器的建模与分析
5. Investigating the role of the MAPK proteins Erk1 and Erk2 on mammalian gametogenesis. [D] . Mohan, Swapna. 2014

机译：研究MAPK蛋白Erk1和Erk2在哺乳动物配子发生中的作用。
6. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK [O] . Claire Letourneux, Géraldine Rocher, Françoise Porteu 2006

机译：含B56的PP2A使ERK脱磷酸其活性受早期基因IEX-1和ERK的控制
7. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK [O] . Letourneux, Claire, Rocher, Géraldine, Porteu, Françoise 2006

机译：含B56的PP2A使ERK脱磷酸，其活性受早期基因IEX-1和ERK的控制
8. ERF is a Potential ERK-Modulated Tumor Suppressor in Prostate Cancer. [R] . Bose, R. 2017

机译：ERF是前列腺癌中潜在的ERK调节的肿瘤抑制剂。

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

摘要

著录项

相似文献

相关主题

期刊订阅