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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Liver resection of hepatocellular carcinoma in patients with portal hypertension and multiple tumors
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Liver resection of hepatocellular carcinoma in patients with portal hypertension and multiple tumors

机译：肝切除的肝细胞癌门脉高压和多个患者肿瘤

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Aim Liver resection for hepatocellular carcinoma (HCC) has been recommended only for patients with a single tumor without portal hypertension. We aimed to validate this treatment strategy that is based on by the Barcelona Clinic Liver Cancer staging system. Methods Patients undergoing liver resection were divided into two groups: patients with single HCC without portal hypertension (Group 1) and those with at least one factors of portal hypertension and multiple tumors, up to three lesions each ≤3?cm (Group 2). We compared survival and postoperative complications between the two groups. Results The median overall and recurrence‐free survival periods of patients in Group 1 ( n ?=?695) were 8.5?years (95% confidence interval [CI], 6.6–9.0) and 2.4?years (2.2–2.7), respectively, and were significantly longer compared with those of patients in Group 2 ( n ?=?197) (5.6?years [95% CI, 4.8–6.7], P ?=?0.001, and 1.9?years [1.6–2.1], P ??0.001). On multivariate analysis, the independent factors for overall survival were hepatitis C virus infection (hazard ratio, 1.29 [95% CI, 1.02–1.65], P ?=?0.032), multiple tumors (1.42 [1.01–1.98], P ?=?0.040), and vascular invasion (1.66 [1.31–2.10], P ??0.001). Frequency of morbidity (23 [3.3%] patients vs 11 [5.5%] patients, P ?=?0.143) and mortality (3 [0.4%] patients vs 2 [1.0%] patients, P ?=?0.305) was not significantly different between the two groups. Conclusions Patients with HCC with portal hypertension and/or multiple tumors could be candidates for liver resection due to the safety of the procedure.
机译：目的对肝细胞癌肝切除(HCC)仅为患者推荐一个肿瘤没有门静脉高压。为了验证这种治疗策略基于由巴塞罗那临床肝癌分期系统。切除被分成两组:病人单肝癌门静脉高压(组1)和至少一个因素门脉高压和多个肿瘤,三个病变≤3 ?生存和术后并发症两组。复发的自由生存期的患者第1组(n = ? 695)是8.5 ?可信区间(CI), 6.6 - -9.0)和2.4吗?(2.2 - -2.7),分别是显著的长相比病人在2组197年(n = ?)(5.6吗?? = 0.001和1.9吗?& ? 0.001)。总体生存的独立因素丙型肝炎病毒感染(风险比1.29(95% CI, 1.02 - -1.65), P ? = ? 0.032),多个肿瘤(1.42 [1.01 - -1.98], P = ? 0.040),和血管入侵(1 . 66[1。10月31 - 2],P ? ? 0.001)。发病率的频率(23(3.3%)患者和11所示0.143(5.5%)患者,P = ?(3)和死亡率(0.4%)患者和2(1.0%)患者,P ? 0.305 = ?)两者之间没有明显不同组。高血压和/或多个肿瘤可能肝切除候选人由于安全的过程。

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