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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Review of angiogenesis in hepatocellular carcinoma
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Review of angiogenesis in hepatocellular carcinoma

机译：肝细胞癌的血管生成

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Hepatocellular carcinoma (HCC) is a hypervascular tumor, and its vascularity is unique and greatly different from peripheral parenchyma of liver. Afferent and efferent vessels of HCC lesions come to differ as the lesion develops. The characteristic of the flow regulates the common style of metastasis. The portal tract of the HCC lesion is the first site of the intrahepatic metastasis, because cancer cells roll into the portal vein via efferent flow. On microscopic observation, HCC displays marked vascular abnormalities, arteriogenesis and capillarization. Arteriogenesis is defined as the growth of functional collateral arteries covered with smooth muscle cells from pre-existing arteries. Sinusoidal capillarization involves the transformation of fenestrated hepatic sinusoids into continuous capillaries. Several angiogenic factors have been reported, and some of them are studied as prognostic factors or target molecules of chemotherapeutic reagents. However, the mechanism of neovascularization during HCC development is still unclear. This review discusses the characteristics of angiogenesis in HCC and known angiogenic factors of HCC.
机译：肝细胞癌(HCC)是其高血管性肿瘤,血管是独一无二的,很大不同于周围肝实质。传入和传出的器皿肝癌病变不同病变的发展。流量调节的共同的特征的转移方式。损伤是肝内的第一个站点癌细胞转移,因为卷到门静脉通过传出流。观察,肝细胞癌显示明显的血管异常,arteriogenesis和斜阳能力。动脉功能间接覆盖的增长既存的平滑肌细胞动脉。的变换有窗的肝血窦在连续的毛细血管。因素已报告,其中一些研究预后因素或目标分子化疗试剂。在肝细胞癌的新血管形成机制发展仍不清楚。讨论了血管生成的特点肝细胞癌和肝癌的血管生成因素。

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