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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid‐enhanced magnetic resonance imaging as a useful detection method for advanced primary biliary cirrhosis
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Gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid‐enhanced magnetic resonance imaging as a useful detection method for advanced primary biliary cirrhosis

机译：Gadolinium‐ethoxybenzyl‐diethylenetriamine五乙酸量增强磁共振成像作为先进的有用的检测方法原发性胆汁性肝硬化

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Aim In primary biliary cirrhosis (PBC), damaged hepatocytes resulting from chronic cholestasis follow a compensatory mechanism that alters hepatobiliary transporter expression to reduce the accumulation of potentially toxic compounds such as bile acid. Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA), has reduced expression in the late stages of PBC. Therefore, we investigated the use of Gd‐EOB‐DTPA‐enhanced magnetic resonance imaging (MRI) as a useful detection method for the advanced staging of PBC. Methods Stage I?III PBC (non‐liver cirrhosis [LC]‐PBC, n ?=?12), stage IV (LC‐PBC, n ?=?6), and non?PBC patients (control group, n ?=?4) were included in this study. We obtained liver tissue samples by percutaneous liver biopsy. Hepatic OATP1B3 expression was determined immunohistochemically, and OATP1B3 mRNA levels were assessed using real‐time reverse transcription polymerase chain reaction. The relative enhancement (RE) in the hepatobiliary phase was calculated using the signal intensity of Gd‐EOB‐DTPA‐enhanced MRI. Results Immunohistochemistry revealed markedly reduced expression of OATP1B3 in hepatocytes around the central vein in LC‐PBC patients. Hepatic OATP1B3 mRNA expression in LC‐PBC patients was significantly lower than that in non‐LC‐PBC patients ( P ??0.05). The RE on MRI was significantly decreased in the LC‐PBC group (0.33?±?0.14) compared with the non‐LC‐PBC (0.91?±?0.15, P ??0.01) and control (0.92?±?0.20, P ??0.01) groups. Conclusion Gd‐EOB‐DTPA‐enhanced MRI may provide a useful detection method for liver disease in patients with LC‐PBC.
机译：目的原发性胆汁性肝硬化(PBC),损坏肝细胞产生的慢性胆汁淤积遵循一个改变的代偿机制肝胆的转运蛋白表达减少潜在的有毒化合物的积累如胆汁酸。肽1 b3 (OATP1B3)运输代理如gadolinium‐ethoxybenzyl‐diethylenetriamine五乙酸(Gd必经区块终止必经二乙三胺五醋酸),减少了表达中国人民银行的后期阶段。我们调查了使用Gd区块地理二乙三胺五醋酸提高磁共振成像(MRI)作为一个有用的检测方法为中国人民银行的高级阶段。方法阶段吗?(LC)检测——中国人民银行,n = ? 12),四期(LC高中国人民银行在n = ? 6),和非吗?纳入本研究。样品经皮肝脏活检。OATP1B3表达决心免疫组织化学,OATP1B3 mRNA水平评估使用实时反向转录聚合酶链反应。肝胆管的相对增强(RE)阶段是使用信号强度计算Gd的区块终止二乙三胺五醋酸还是提高核磁共振。免疫组织化学显示明显下降肝细胞的OATP1B3的表情中央静脉LC PBC患者。信使rna表达LC PBC患者显著低于非必经LC的中国人民银行患者(P & ? 0.05)。显著降低LC检测——中国人民银行集团(0.14±0.33 ?)而非必经LC的中国人民银行(±0.91 ? 0.15,P ? & ? 0.01)和控制(±0.92 ? 0.20,P ? & ? 0.01)组。Gd重心区块地理二乙三胺五醋酸提高MRI可以提供一个有用的肝病患者的检测方法与信用证的中国人民银行。

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