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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Selective aldosterone blocker, eplerenone, attenuates hepatocellular carcinoma growth and angiogenesis in mice.
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Selective aldosterone blocker, eplerenone, attenuates hepatocellular carcinoma growth and angiogenesis in mice.

机译：选择性醛固酮受体阻断剂,eplerenone,变弱和肝细胞癌增长血管生成在老鼠身上。

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Aim: The renin-angiotensin-aldosterone system (RAAS) has become known as a prerequisite for tumor angiogenesis, including hepatocellular carcinoma (HCC). Although angiotensin II is known to play an important role in tumor growth and angiogenesis, the role of aldosterone (Ald) is still obscure. The aim of our current study was to elucidate the effect of eplerenone, a clinically used selective Ald blocker (SAB), on murine HCC development especially in conjunction with angiogenesis. Methods: To create an allograft model, we injected 1 x 10(6) of BNL-HCC cells into the flanks of BALB/c mice. After the tumor was established, SAB was administrated at dose of 100 mg/kg per day. Results: Administration of SAB significantly suppressed HCC development along with inhibition of angiogenesis and expression of the vascular endothelial growth factor (VEGF), a potent angiogenic factor. SAB treatment resulted in a marked increase of apoptosis in the tumor, whereas tumor cell proliferation was not altered. Our in vitro study showed that SAB significantly suppressed the Ald-induced endothelial proliferation and tubular formation through inhibition of phosphorylation of the extracellular signal-regulated kinase 1/2. On the contrary, neither Ald nor SAB affected the proliferation of HCC cells in vitro. Conclusion: Ald plays a pivotal role in HCC development through VEGF-mediated tumor angiogenesis, and SAB may be a potential new strategy in HCC therapy in the future.
机译：目的:肾素血管紧张素醛固酮系统(老城)已经成为众所周知的先决条件肿瘤血管生成,包括肝细胞癌(HCC)。在肿瘤的生长和发挥着重要的作用血管生成,醛固酮(Ald)的作用仍然模糊。阐明eplerenone的影响,临床使用选择性Ald拦截器(SAB)小鼠肝细胞癌发展特别是在一起与血管生成。同种异体移植物模型,我们1 x 10 (6) BNL-HCC注入细胞植入BALB / c小鼠的侧翼。建立了肿瘤,SAB管理每天剂量100毫克/公斤。政府SAB显著抑制肝癌发展的抑制血管的血管生成和表达血管内皮生长因子(VEGF),一个强有力的血管生成因子。显著增加细胞凋亡的肿瘤,而肿瘤细胞增殖并没有改变。我们的体外研究表明,SAB显著抑制了Ald-induced内皮核扩散和管状形成磷酸化的抑制细胞外signal-regulated激酶1/2。相反,退化和SAB都不影响肝癌细胞体外增殖。Ald在肝癌发展中起着举足轻重的作用通过VEGF-mediated肿瘤血管生成、审计局可能是一个潜在的新战略在肝癌治疗未来。

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