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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >lambda-Interferons and the single nucleotide polymorphisms: A milestone to tailor-made therapy for chronic hepatitis C.
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lambda-Interferons and the single nucleotide polymorphisms: A milestone to tailor-made therapy for chronic hepatitis C.

机译：lambda-Interferons和单核苷酸多态性:特制的治疗一个里程碑慢性丙型肝炎。

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摘要

Type III interferons (IFN) (IFN-lambda1, -lambda2, -lambda3/interleukin [IL]-29, -28A, -28B) are cytokines with type I IFN-like antiviral activities. Most cells have expressed both type I and III IFN following Toll-like receptor (TLR) stimulation or viral infection, whereas the ability of cells to respond to IFN-lambda was restricted to a specific subset of cells. It was reported that signal transduction pathway of IFN-lambda was similar to that of IFN-alpha/beta although a receptor adapted by IFN-lambda were distinct from that of IFN-alpha/beta. However, the clinical significance and the role of each IFN-lambda were unclear. Recent genome-wide association studies (GWAS) of the human whole genome revealed several single nucleotide polymorphism sites (SNP) strongly associated with the response to pegylated IFN-alpha (PEG-IFN) plus ribavirin (RBV) treatment in chronic hepatitis C patients. The SNP, which are located near the IL-28B gene of chromosome 19, were discovered simultaneously by three independent studies opening a new prospective in hepatitis C research. The present review highlights significant insights that can be derived from the GWAS approach, and summarizes current knowledge of in vitro and in vivo study on the role of IFN-lambda in antiviral effect.
机译：III型干扰素(IFN) (IFN-lambda1 -lambda2,-lambda3 /白介素(IL) -29, -28, -28 b)细胞因子与I型IFN-like抗病毒活动。和III干扰素toll样受体(TLR)刺激或病毒感染,而细胞的能力应对IFN-lambda细胞的限制到一个特定的子集。报道称,信号转导通路IFN-lambda类似IFN-alpha /β尽管受体IFN-lambda改编的不同于IFN-alpha /β。的临床意义和作用IFN-lambda都不清楚。关联研究(GWAS)人类的整体基因组显示几个单核苷酸多态性(SNP)密切相关的网站对聚乙二醇的反应IFN-alpha (PEG-IFN)联合利巴韦林治疗慢性(各类单体)丙型肝炎患者。IL-28B附近基因的染色体19日同时发现了三个独立的在丙型肝炎研究打开一个新的未来研究。重要的见解,可以派生的GWAS的方法,总结了当前的知识在体外和体内研究的作用IFN-lambda抗病毒效应。

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