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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters.
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Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters.

机译：Chymase抑制变弱tetrachloride-induced仓鼠肝纤维化。

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Aim: Chymase converts angiotensin I to angiotensin II, which may promote the development of liver fibrosis. In this study, whether a chymase inhibitor TY-51469 attenuated tetrachloride (CCl(4))-induced liver fibrosis was examined. Methods: Liver fibrosis was induced by the s.c. injection of 1 mL/kg of CCl(4) twice weekly for 8 weeks, and each hamster was given TY-51469 (1 mg/kg per day) or placebo. Untreated hamsters were used as a control group. Results: Significant increases of serum alanine aminotransferase, total bilirubin and hyaluronic acid levels were observed in the placebo-treated group compared with the control group, but these levels were significantly attenuated in the TY-51469-treated group. Liver chymase activity was significantly higher in the placebo-treated group than in the control group, whereas the activity in the TY51469-treated group was not. Total angiotensin II-forming activity in the liver was also significantly higher in the placebo-treatedgroup than in the control group or the TY-51469-treated group. The ratio of the fibrotic area to the total area in the liver was significantly higher in the placebo-treated group than in the control group, but the ratio was significantly lower in the TY-51469-treated group than in the placebo-treated group. A significant decrease in the number of alpha-smooth muscle actin (SMA)-positive cells was seen in the TY-51469-treated group compared to the placebo-treated group. Conclusion: Significant correlations between the number of chymase-positive cells and the degree of fibrosis and between the numbers of chymase-positive cells and alpha-SMA-positive cells were observed. Thus, chymase inhibition may be a useful strategy for preventing liver fibrosis.
机译：目的:Chymase血管紧张素I转换为血管紧张素二世,这可能促进肝脏的发展纤维化四氯化剂ty - 51469减毒(CCl(4)分部)全身检查肝纤维化。方法:肝纤维化是南卡罗来纳州的诱导。CCl注射1毫升/公斤(4)两次每周8周,每个仓鼠是ty - 51469 (1毫克/公斤/天)或安慰剂。作为对照组。血清丙氨酸的显著增加转氨酶、总胆红素和透明质酸酸水平在服用对照观察组与对照组相比,但这些水平明显下降ty - 51469治疗组。在安慰剂组明显高于组比对照组,而TY51469-treated组的活动。血管紧张素II-forming活动肝脏也显著提高比对照组或placebo-treatedgroupty - 51469治疗组。肝纤维化区域的总面积明显高于安慰剂组比在对照组,但比ty - 51469治疗组显著降低比接受安慰剂组。数量的减少alpha-smooth肌肉肌动蛋白(SMA)阳性细胞的ty - 51469治疗组相比安慰剂组。的数量之间的相关性chymase-positive细胞和纤维化的程度和chymase-positive数字之间的细胞和alpha-SMA-positive细胞观察。chymase抑制可能是一个有用的策略防止肝纤维化。

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