NLRP1-One NLR to guard them all

Lacey Carolyn A.; Miao Edward A.

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NLRP1-One NLR to guard them all

机译：NLRP1-One NLR来保护他们

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Microbial pathogens can be detected by inflammasomes that induce inflammation and programmed cell death. Inflammasomes are sensors that survey cells for signs of compromise. One of these sensors, NLRP1, detects anthrax lethal toxin; however, the mechanism of NLRP1 activation has remained unknown. Here, Xu et al discover NLRP1 cleavage by lethal toxin induces the N-end rule, which targets NLRP1 for degradation. Surprisingly, the active inflammasome fragment escapes the proteasome and becomes an activate inflammasome itself.

机译：可以检测到微生物病原体inflammasomes诱导炎症和程序性细胞死亡。调查细胞妥协的迹象。NLRP1,这些传感器检测炭疽致命的毒素;仍然未知。致命的毒素诱发N-end NLRP1乳沟规则,目标NLRP1退化。令人惊讶的是,主动inflammasome片段逃的蛋白酶体和成为一个激活inflammasome本身。

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来源
《The EMBO journal.》 |2019年第13期|e102494-e102494|共3页
作者
Lacey Carolyn A.; Miao Edward A.;
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作者单位

Univ N Carolina, Dept Microbiol & Immunol, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515;

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原文格式 PDF
正文语种英语
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关键词
N-end; NLRP1 gene; InflammasomesProteasome Endopeptidase ComplexSensorsAnthrax toxin lethal toxin;

机译：N-end;NLRP1基因;InflammasomesProteasome肽链内切酶ComplexSensorsAnthrax毒素致命毒素;

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NLRP1-One NLR to guard them all

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