Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome

Maass Philipp G.; Weise Anja; Rittscher KatharinaLichtenwald JuliaBarutcu A. RasimLiehr ThomasAydin AtakanWefeld-Neuenfeld YvettePoelsler LauraTinschert SigridRinn John L.Luft Friedrich C.Baehring Sylvia

首页> 外文期刊>The EMBO journal. >Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome

【24h】

Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome

机译：重组inter-chromosomal交互在2 q37-deletion综合症

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Chromosomes occupy distinct interphase territories in the three-dimensional nucleus. However, how these chromosome territories are arranged relative to one another is poorly understood. Here, we investigated the inter-chromosomal interactions between chromosomes 2q, 12, and 17 in human mesenchymal stem cells (MSCs) and MSC-derived cell types by DNA-FISH. We compared our findings in normal karyotypes with a three-generation family harboring a 2q37-deletion syndrome, featuring a heterozygous partial deletion of histone deacetylase 4 (HDAC4) on chr2q37. In normal karyotypes, we detected stable, recurring arrangements and interactions between the three chromosomal territories with a tissue-specific interaction bias at certain loci. These inter-chromosomal interactions were confirmed by Hi-C. Interestingly, the disease-related HDAC4 deletion resulted in displaced inter-chromosomal arrangements and altered interactions between the deletion-affected chromosome 2 and chromosome 12 and/or 17 in 2q37-deletion syndrome patients. Our findings provide evidence for a direct link between a structural chromosomal aberration and altered interphase architecture that results in a nuclear configuration, supporting a possible molecular pathogenesis.

机译：染色体占据不同相间的领土在三维核。这些染色体区域排列相对于彼此了解甚少。在这里,我们调查了inter-chromosomal染色体2 q之间的相互作用、12和17在人类间充质干细胞(msc)和由DNA-FISH MSC-derived细胞类型。我们的发现在正常核型形成三代家庭窝藏2 q37-deletion综合症,杂合的部分删除组蛋白脱乙酰酶4 (HDAC4)chr2q37。稳定,重复安排和交互三染色体之间的领土了组织交互偏见在特定位点。这些inter-chromosomal交互证实了高c。疾病HDAC4删除了流离失所inter-chromosomal安排和改变之间的相互作用deletion-affected 2号染色体和染色体12和/或17 2 q37-deletion综合症患者。发现提供了证据,直接的联系结构染色体畸变和之间改变导致的界面体系结构核配置,支持成为可能分子发病机制。

著录项

来源
《The EMBO journal.》 |2018年第15期|e96257-e96257|共16页
作者
Maass Philipp G.; Weise Anja; Rittscher KatharinaLichtenwald JuliaBarutcu A. RasimLiehr ThomasAydin AtakanWefeld-Neuenfeld YvettePoelsler LauraTinschert SigridRinn John L.Luft Friedrich C.Baehring Sylvia;
展开▼
作者单位

ECRC, Charite Med Fac & Max Delbruck Ctr Mol Med MDC, Berlin, Germany;

Max Delbruck Ctr Mol Med MDC, Berlin, Germany;

Med Univ, Zentrum Med Genet, Innsbruck, AustriaHarvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USAFriedrich Schiller Univ, Jena Univ Hosp, Inst Human Genet, Jena, Germany;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Reorganisation; Histone Deacetylases; HDAC4 geneSyndromesNormal karyotypehome rangeChromosome TerritoryKaryotypeInterphaseChromosomes;

机译：重组;Histone Deacetylases;HDAC4geneSyndromesNormal karyotypehome rangeChromosomeTerritoryKaryotypeInterphaseChromosomes;

相似文献

外文文献
中文文献
专利

1. Critical role of cytochrome c1 and its cleavage in porcine reproductive and respiratory syndrome virus nonstructural protein 4-induced cell apoptosis via interaction with nsp4 [J] . ZHANG Feng, GAO Peng, GE Xin-na, 农业科学学报（英文版） . 2017,第011期
2. LEOPARD症候群，多発性黒子症候群， ^u>Moynahan症候群LEOPARD syndrome, multiple lentigines syndrome, Moynahan syndrome [J] . 宮崎睦子, 近藤達郎日本臨牀 . 2014,第别册：神经症候群29期

机译：LEOPARD症候群，多発性黒子症候群， ^u>Moynahan症候群LEOPARD syndrome, multiple lentigines syndrome, Moynahan syndrome
3. LEOPARD症候群，多発性黒子症候群， ^u Moynahan症候群LEOPARD syndrome, multiple lentigines syndrome, Moynahan syndrome [J] . 宮崎睦子, 近藤達郎日本臨牀 . 2014,第别册：神经症候群29期

机译：LEOPARD症候群，多発性黒子症候群， ^u>Moynahan症候群LEOPARD syndrome, multiple lentigines syndrome, Moynahan syndrome
4. Huang, Chun-chieh (Junjie) 黃俊杰, The Confucian Classics and Their Ideas in the Cultural Interaction in East Asia: Interaction, Transformation, and Syntheses 東亞文化交流中的儒家經典與理念:互動、轉化與融合 [J] . Liangjian Liu Dao . 2012,第3期

机译：Huang, Chun-chieh (Junjie) 黄俊杰, The Confucian Classics and Their Ideas in the Cultural Interaction in East Asia: Interaction, Transformation, and Syntheses 东亚文化交流中的儒家经典与理念:互动、转化与融合
5. Adaptive image steganography based on Syndrome-Trellis codes [C] . T. R. Preetha, V Jyothis International Conference on Computing, Communication and Networking Technologies . 2017

机译：基于Syndrome-Trellis代码的自适应图像隐写术
6. Control of Light-matter Interactions via Nanostructured Photonic Materials =通过纳米结构光子材料控制光物质相互作用 [D] . Proscia, Nicholas V. 2019

机译：Control of Light-matter Interactions via Nanostructured Photonic Materials =通过纳米结构光子材料控制光物质相互作用
7. Understanding Host–Pathogen Interactions in [O] . Ting Xiang Neik, Junrey Amas, Martin Barbetti, 2020

机译：了解Host-Pathogen Interactions
8. Síndrome do disco adjacente à fusão (Síndrome de Transição) na coluna cervical: resultados segundo critérios clínicos e radiológicos Síndrome del disco adyacente a la fusión (Síndrome de Transición) en la columna cervical Adjacent segment disease (Transitional Syndrome) in cervical spine: clinical and radiological results [O] . Alexandre Meluzzi, Mário Augusto Taricco, Vinícius Monteiro de Paula Guirado, 2010

机译：融合椎间盘综合征（Transition syndrome）附近的颈椎：根据临床和放射学标准的结果颈椎中的辅助融合椎间盘综合征（Transition syndrome）颈椎相邻节段性疾病（Transitional syndrome）：临床和放射学结果
9. Turtle-Scallop Dredge Interaction Study, 2005 Field Season. [R] . Smolowitz, R., Weeks, M. 2006

机译：Turtle-scallop Dredge Interaction study，2005 Field season。

Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome

摘要

著录项

相似文献

相关主题

期刊订阅