Growing a gasdermin pore in membranes of pyroptotic cells

Ding Jingjin; Shao Feng

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Growing a gasdermin pore in membranes of pyroptotic cells

机译：膜的gasdermin孔隙pyroptotic细胞

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Inflammasome-activated caspase-1, caspase-11, caspase-4, and caspase-5 cleave GSDMD to unleash its N-terminal gasdermin-N domain (GSDMD(Nterm)) that perforates the plasma membrane to execute pyroptosis and stimulate inflammation. The mechanism underlying GSDMD(Nterm) pore formation is unclear. Mulvihill et al use high-resolution atomic force microscopy (AFM) to analyze the dynamic pore formation process of GSDMD(Nterm). GSDMD(Nterm) protomers are inserted into the lipid membrane to assemble arc- or slit-shaped oligomers that can incorporate additional protomers and grow into large and stable ring-shaped oligomers to form pores.

机译：Inflammasome-activated caspase-1 caspase-11,caspase-4, caspase-5裂开GSDMD释放其氨基端gasdermin-N域(GSDMD (Nterm))执行,使质膜穿孔pyroptosis并刺激炎症。机制GSDMD (Nterm)孔隙的形成目前还不清楚。原子力显微镜(AFM)分析动态孔隙的形成过程GSDMD (Nterm)。GSDMD (Nterm)插入到原体脂质膜组装弧或slit-shaped可以将额外的低聚物原体和成长为大型的和稳定的环状低聚物形成气孔。

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来源
《The EMBO journal.》 |2018年第15期|e100067-e100067|共3页
作者
Ding Jingjin; Shao Feng;
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作者单位

Natl Inst Biol Sci, Beijing, Peoples R China;

Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing;

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正文语种英语
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关键词
Atomic Force Microscopy; Protomers; oligomerscaspase 11Pore formationmembranelipid membraneCaspase-5CASP4 protein, humanPlasma membraneformation process;

机译：原子力显微镜;原体;oligomerscaspase11孔formationmembranelipidmembraneCaspase-5CASP4蛋白质,humanPlasmamembraneformation过程;

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Growing a gasdermin pore in membranes of pyroptotic cells

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