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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Usefulness of scintigraphy with technetium-99m galactosyl human serum albumin in prediction of prognosis of primary biliary cirrhosis.
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Usefulness of scintigraphy with technetium-99m galactosyl human serum albumin in prediction of prognosis of primary biliary cirrhosis.

机译：实用性锝99 m的显像半乳糖在预测人类血清白蛋白原发性胆汁性肝硬化的预后。

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摘要

Prediction of survival of patients with primary biliary cirrhosis (PBC) has been based on results of blood tests and other indices of clinical condition, which may be affected by treatment. We earlier evaluated hepatic receptor imaging with 99mTc galactosyl human serum albumin as an alternative method for prediction of survival. To evaluate whether this method is useful for this purpose, we examined the cumulative survival rate of patients with PBC since their first examination by this method. The subjects were 60 patients with PBC, 10 healthy subjects, 65 patients with chronic hepatitis, and 196 patients with cirrhosis. Computer acquisition of gamma-camera data was started just before the injection of 99mTc galactosyl human serum albumin and was stopped 20 min later. As indices of hepatic functional reserve, the receptor index and the index of blood clearance were calculated. Among the patients with PBC, the receptor index was lower in those with stage IV than in those with stages I, II, or III, and the index of blood clearance was higher in patients with stage IV than in those with stages I, II, or III. On the basis of the receptor index, the patients with PBC were divided arbitrarily into two groups of roughly equal size: group A with a receptor index of greater-than-or-equal0.94, and group B with index <0.94. On the basis of the index of blood clearance, the patients were also divided into two groups of roughly equal size: group C with an index of blood clearance of <0.52, and group D with index greater-than-or-equal0.52. Cumulative survival rates were significantly lower in group B than in group A (P=0.026), and lower in group D than in group C (P=0.005). Regression analysis showed the index of blood clearance to be significantly related to survival. In conclusion, hepatic receptor imaging with 99mTc galactosyl human serum albumin can be used to noninvasively evaluate the hepatic functional reserve of patients with PBC and is useful clinically in establishing their prognosis.
机译：预测患者主要的生存胆汁性肝硬化(PBC)是基于结果血液测试和其他临床指标条件,这可能会影响到治疗。早期评估肝受体显像99年人类血清白蛋白作为矿渣mtc半乳糖替代方法预测的生存。评估这个方法是否有用目的,我们检查了累积生存率PBC患者因为他们的第一个用这种方法检查。PBC患者,10个健康受试者,65慢性肝炎患者,196例患者与肝硬化。射线照相机数据开始之前人类血清白蛋白注射99矿渣mtc半乳糖20分钟后,停止。肝储备功能,受体指数和血液间隙计算的指数。在PBC患者中,受体指数在那些低四期比吗阶段我、II或III,血液的指数间隙是四期的患者更高我比那些阶段,II或III。受体指数的基础上,患者中国人民银行被随机分为两组大致相等的大小:A组与受体指数greater-than-or-equal0.94, B组指数< 0.94。间隙,病人也分成两组大致相等大小:C组的血液清除指数< 0.52,D组与指数greater-than-or-equal0.52。存活率在组显著降低B组(P = 0.026),在D组和低比在C组(P = 0.005)。显示,该指数的血液间隙生存显著相关。肝受体显像与99矿渣mtc半乳糖人血清白蛋白可以使用动物评估肝储备功能的PBC患者和临床中非常有用建立他们的预后。

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