...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Distinctive clinicopathological features and KRAS KRAS and IDH IDH 1/2 mutation status of cholangiolocellular carcinoma
【24h】

Distinctive clinicopathological features and KRAS KRAS and IDH IDH 1/2 mutation status of cholangiolocellular carcinoma

机译：独特的临床病理特点及喀斯特喀斯特和IDH IDH 1/2突变状态cholangiolocellular癌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim Cholangiolocellular carcinoma (CLC) is classified as a subtype of combined hepatocellular cholangiocarcinoma with stem‐cell features (CHC‐SC) in the latest World Health Organization classification. This subclassification of CHC‐SCs is controversial and the relevance of such classification is unclear. Methods We analyzed a series of CHC‐SCs and intrahepatic cholangiocarcinoma (iCCA) to clarify the clinicopathological features and mutational status of each tumor. Results Background liver disease, fibrosis stage, microvascular invasion, nodal metastasis, and IDH1/2 mutation status were associated with their histology. Compared with the intermediate cell subtype of CHC‐SC (CHCs‐SC‐int), CLCs were less frequently associated with chronic viral hepatitis, and showed lower levels of serum alpha‐fetoprotein. Compared with iCCAs, CLCs showed lower levels of serum carbohydrate antigen 19‐9 (CA19‐9) and a lower frequency of expression of S100P. Patients with iCCA showed worse overall survival than those with CLC or CHC‐SC‐int. In patients with iCCA, CLC, or CHC‐SC‐int, a histology of iCCA, microvascular invasion, and serum CA19‐9 value of 100 U/mL were significant poor prognostic factors for overall survival in univariate analysis. Multivariate analysis showed that a high serum CA19‐9 value was an independent poor prognostic factor for overall survival. Conclusions Patients with CLC are likely to have a different etiology and mutational background from those with CHC‐SC‐int. Their clinicopathological manifestations are also different from those with classic iCCA. Our results suggest that CLC might be a distinct entity among primary liver carcinomas.
机译：目的Cholangiolocellular癌(CLC)列为一种亚型的总和肝细胞与胆管癌干细胞的细胞地理特性(CHC SC)在最新的世界卫生组织分类。子分类的CHC SCs是有争议的这种分类的相关性尚不明确。方法分析一系列CHC SCs和肝内胆管癌(iCCA)澄清临床病理的特点和突变每个肿瘤的地位。疾病、肝纤维化阶段,微血管入侵,淋巴结的转移,IDH1/2突变状态与他们的组织学。中间细胞亚型CHC SC(CHCs必经SC必经int), clc较少与慢性病毒性肝炎有关,表现出低水平的血清α胎蛋白。与iCCAs相比,clc显示低水平的血清糖类抗原19 9 (CA19 9)应承担的和S100P低频率的表达式。与iCCA显示总体存活率比那些CLC或者CHC SC int。iCCA CLC,或者CHC SC高int iCCA组织学,微血管入侵和血清CA19 9的价值在100 U /毫升是重要的预后不佳因素单变量的整体存活率分析。高血清CA19 9应承担的值是一个独立的贫穷总生存期的预后因素。结论CLC患者可能会有不同的病因和突变背景从那些CHC必经SC int。临床病理的表现也不同于那些经典iCCA。结果表明,CLC可能是截然不同的实体在原发性肝细胞癌。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号