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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Clinical significance and function of RDH16 RDH16 as a tumor‐suppressing gene in hepatocellular carcinoma
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Clinical significance and function of RDH16 RDH16 as a tumor‐suppressing gene in hepatocellular carcinoma

机译：临床意义和功能RDH16 RDH16作为一个肿瘤抑制基因在肝细胞中癌

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摘要

Aim Our previous transcriptome sequencing analysis detected that retinol dehydrogenase?16 ( RDH16 ) was dramatically downregulated in hepatocellular carcinoma (HCC). RDH16 belongs to the short‐chain dehydrogenases/reductases super family, and its role in HCC remains unknown. This study aimed to investigate the expression and function of RDH16 in HCC. Methods The mRNA and protein level of RDH16 in HCC samples were detected by quantitative real‐time polymerase chain reaction and immunohistochemistry analyses, respectively. The role of RDH16 in HCC was determined by in?vitro and in?vivo functional studies. Results Downregulation of RDH16 has been detected in approximately 90% of primary HCCs, which was significantly associated with high serum alpha‐fetoprotein level, tumor size, microsatellite formation, thrombus, and poor overall survival of HCC patients. Compared with non‐tumor tissues, higher density of methylation was identified in HCC samples. In addition, RDH16 increases the level of retinoic acid and blocks the de novo synthesis of fatty acid in HCC cells. Functional study shows that ectopic expression of RDH16 in HCC cells suppresses cell growth, clonogenicity, and cell motility. Conclusions RDH16 might be a prognostic biomarker and intervention point for new therapeutic strategies in HCC.
机译：目的我们之前的转录组测序分析检测到视黄醇脱氢酶吗?在肝细胞大幅下调吗癌(HCC)。脱氢酶/还原酶超家族,其肝癌作用仍然是未知的。调查RDH16的表达和功能在肝细胞癌。RDH16肝癌样本被检测到定量实时聚合酶链反应分别和免疫组织化学分析。由RDH16在肝癌中的作用在吗?Downregulation RDH16被检测到大约有90%的原发性肝细胞癌,这是高血清显著相关α检测胎蛋白水平、肿瘤大小、微卫星的形成、血栓和贫穷肝癌患者的总体生存。非高肿瘤组织在更高密度的甲基化在肝癌样品确认。增加的程度视黄酸和块的从头合成脂肪酸在肝细胞。功能的研究表明,异位表达RDH16在肝癌细胞抑制细胞生长,clonogenicity,细胞的能动性。RDH16预后的生物标志物和干预点新的治疗策略在HCC。

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