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首页> 外文期刊>EMBO Journal >RNAi is antagonized by A - I hyper-editing
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RNAi is antagonized by A - I hyper-editing

机译：- 我hyper-editing RNAi是得罪了

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摘要

RNA interference (RNAi) and adenosine to inosine conversion are both mechanisms that respond to double-stranded RNA (dsRNA) and have been suggested to have antiviral roles. RNAi involves processing of dsRNA to short interfering RNAs (siRNAs), which subsequently mediate degradation of the cognate mRNAs. Deamination of adenosines changes the coding capacity of the RNA, as inosine is decoded as guanosine, and alters the structure because A-U base pairs are replaced by I .U wobble pairs. Here we show that RNAi is inhibited if the triggering dsRNA is first deaminated by ADAR2. Moreover, we show that production of siRNAs is progressively inhibited with increasing deamination and that this is sufficient to explain the inhibition of RNAi upon hyper-editing of dsRNAs.
机译：核糖核酸干扰(RNAi)和腺苷肌苷转换都是应对机制双链RNA(极)和建议有抗病毒的作用。处理的极短干扰rna(siRNAs),随后调解退化同源mrna。改变RNA的编码能力,肌苷解码是鸟嘌呤核苷,改变了结构因为u碱基对所取代我.U摆动对。如果触发dsRNA首先抑制由ADAR2脱氨基。siRNAs逐步抑制生产随着脱氨基作用,这是足以解释RNAi的抑制hyper-editing dsrna。

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