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首页> 外文期刊>EMBO Journal >Generating patterns from fields of cells - Examples from Drosophila segmentation [Review]
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Generating patterns from fields of cells - Examples from Drosophila segmentation [Review]

机译：从领域的细胞——生成模式例子从果蝇分割(审查)

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摘要

In Drosophila, a cascade of maternal, gap, pair-rule and, segment polarity genes subdivides the antero/posterior axis of the embryo into repeating segmental stripes. This review, summarizes what happens next, i.e. how an intrasegmental, pattern is generated and controls the differentiation of specific cell types in the epidermis. Within each segment, cells secreting the signalling molecules Wingless (the homologue of vertebrate Wnt-1) and Hedgehog are found in narrow stripes on both sides of the parasegmental boundary. The Wingless and Hedgehog organizing activities help to establish two more stripes per segment that localize ligands for the Epidermal Growth Factor and the Notch signalling pathways, respectively. These four signals then act at short range and in concerti to control epidermal differentiation at the single cell level across the segment. This example from Drosophila provides a paradigm for how organizers generate precise patterns, and ultimately different cell types, in a naive field of cells.
机译：在果蝇中,一连串的孕产妇、差距,配对原则,将段极性基因antero /后胚胎为轴心重复段条纹。总结了接下来会发生什么,即如何intrasegmental,生成和控制模式中的特定细胞类型的分化表皮。信号分子的无翼(同系物发现脊椎动物Wnt-1)和刺猬窄条纹parasegmental的两边边界。活动有助于建立两个条纹/段定位为表皮配体生长因子和Notch信号通路,分别。短程和协奏曲控制表皮在单细胞水平分化段。组织者如何生成提供了一个范式精确的模式,最终不同的细胞的细胞类型,在一个天真的字段。

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