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首页> 外文期刊>EMBO Journal >Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole.
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Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole.

机译：弓形虫evacuoles:一个两步的过程分泌和融合形成了parasitophorous液泡。

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摘要

Rapid discharge of secretory organelles called rhoptries is tightly coupled with host cell entry by the protozoan parasite Toxoplasma gondii. Rhoptry contents were deposited in clusters of vesicles within the host cell cytosol and within the parasitophorous vacuole. To examine the fate of these rhoptry-derived secretory vesicles, we utilized cytochalasin D to prevent invasion, leading to accumulation of protein-rich vesicles in the host cell cytosol. These vesicles lack an internal parasite and are hence termed evacuoles. Like the mature parasite-containing vacuole, evacuoles became intimately associated with host cell mitochondria and endoplasmic reticulum, while remaining completely resistant to fusion with host cell endosomes and lysosomes. In contrast, evacuoles were recruited to pre-existing, parasite-containing vacuoles and were capable of fusing and delivering their contents to these compartments. Our findings indicate that a two-step process involving direct rhoptry secretion into the host cell cytoplasm followed by incorporation into the vacuole generates the parasitophorous vacuole occupied by TOXOPLASMA: The characteristic properties of the mature vacuole are likely to be determined by this early delivery of rhoptry components.
机译：分泌的细胞器的快速放电rhoptries与宿主细胞紧密耦合的条目由原生动物寄生虫刚地弓形虫。Rhoptry内容存入的在宿主细胞胞质内小泡parasitophorous液泡。这些rhoptry-derived分泌小泡,我们利用细胞松弛素D,以防止入侵,导致积累富含蛋白质的囊泡在宿主细胞胞质。内部寄生虫,因此称为evacuoles。喜欢成熟parasite-containing泡,evacuoles成为密切与主机相关联细胞线粒体和内质网,同时保持完全的融合宿主细胞核内体和溶酶体。相反,evacuoles招募预先存在的,parasite-containing液泡能够融合和交付他们吗内容这些隔间。涉及直接的表明一个两步的过程rhoptry分泌进入宿主细胞的细胞质中其次是并入液泡生成parasitophorous泡了弓形虫:特征的属性成熟的液泡可能由早期交付rhoptry组件。

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