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首页> 外文期刊>EMBO Journal >Molecular markers of serine protease evolution.
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Molecular markers of serine protease evolution.

机译：丝氨酸蛋白酶进化的分子标记。

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摘要

The evolutionary history of serine proteases can be accounted for by highly conserved amino acids that form crucial structural and chemical elements of the catalytic apparatus. These residues display non- random dichotomies in either amino acid choice or serine codon usage and serve as discrete markers for tracking changes in the active site environment and supporting structures. These markers categorize serine proteases of the chymotrypsin-like, subtilisin-like and alpha/beta-hydrolase fold clans according to phylogenetic lineages, and indicate the relative ages and order of appearance of those lineages. A common theme among these three unrelated clans of serine proteases is the development or maintenance of a catalytic tetrad, the fourth member of which is a Ser or Cys whose side chain helps stabilize other residues of the standard catalytic triad. A genetic mechanism for mutation of conserved markers, domain duplication followed by gene splitting, is suggested by analysis of evolutionary markers from newly sequenced genes with multiple protease domains.
机译：丝氨酸蛋白酶的进化历史被高度保守的氨基酸占形成关键结构和化学元素的催化装置。残留显示非随机二分法氨基酸的选择或丝氨酸密码子使用和作为跟踪离散的标记变化的环境和活跃的站点支持结构。chymotrypsin-like丝氨酸蛋白酶,subtilisin-like和α/ beta-hydrolase褶皱根据系统发育血统家族,和表示的相对年龄和秩序外表的血统。其中三个不相关的丝氨酸的氏族蛋白酶的开发或维护催化四分体,这是一个的第四个成员Ser或半胱氨酸的侧链帮助稳定残留标准的催化三分子。的遗传变异机制守恒的标记,域重复基因紧随其后分裂,由分析建议进化从新测序的基因标记与多个蛋白酶域。

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