...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of cancer >Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours.
【24h】

Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours.

机译：妳酪氨酸激酶受体的过度在皮肤SCC-derived细胞系和肿瘤。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorly understood. We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell that mimic disease progression with the aim of identifying genes that may potentially contribute towards squamous cell carcinoma (SCC) progression in vivo, and in particular to identify markers that may serve as potential therapeutic targets for SCC treatment. Gene expression differences were corroborated by polymerase chain reaction and Western blotting. We identified Axl, a receptor tyrosine kinase with transforming potential that has also been shown to have a role in cell survival, adhesion and chemotaxis, was upregulated in vitro in SCC-derived cells compared to premalignant cells. Extending the investigation to tumour biopsies showed that the Axl protein was overexpressed in vivo in a series of SCCs.
机译：背后的分子机制皮肤鳞状细胞癌的发展(SSC)也不太清楚。寡核苷酸微阵列比较细胞基因表达之间的差异一系列的角化细胞细胞模拟疾病发展目标是识别基因这可能对鳞状贡献体内细胞癌进展,可以作为特定的识别标记鳞状细胞癌的潜在治疗靶点治疗。证实了基因表达差异聚合酶链反应和免疫印迹。我们确定了妳的受体酪氨酸激酶改造潜力也有一个角色在细胞生存,附着力和趋化性调节体外相比SCC-derived细胞癌变前的细胞。扩展调查肿瘤活检表明,妳蛋白过表达体内的一系列癌。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号