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首页> 外文期刊>The British journal of cancer >Role of lymphangiogenesis in epithelial ovarian cancer.
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Role of lymphangiogenesis in epithelial ovarian cancer.

机译：lymphangiogenesis在卵巢上皮的作用癌症。

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摘要

We investigated the significance of lymphatic count, vascular count and angiogenic growth factors using immunohistochemistry in 108 tumour specimens of epithelial ovarian cancer with antibodies to lymphatic vessel endothelial hyaluronan receptor (LYVE-1), platelet endothelial cell adhesion molecule CD31, vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) in epithelial ovarian cancer to understand the pathogenesis of metastasis in ovarian cancer. The effect of prognostic variables on progression-free and overall survival was assessed. On multivariate analysis, bulky residual disease after surgery was the best prognostic indicator (P<0.001) for progression-free and overall survival (P<0.001). Lymphatic count was statistically significant as a prognostic factor for progression-free (P=0.05) and overall survival (P=0.04). However, lymphatic count did not impact on survival curves. No correlation was found between lymphatic count and age, histological subtype, FIGO stage or residual disease. Vascular count, VEGF or TP expressions were not significant in either analysis. Lymphatic spread may be significant in aiding metastases in ovarian cancer but requires other biological factors to act in conjunction, as it does not have clearcut prognostic significance. Dissemination of ovarian cancer does not occur primarily through vascular or lymphatic routes but may occur through direct intraperitoneal spread of disease.
机译：我们研究了淋巴的重要性计数,计数和血管血管生成生长使用108年肿瘤免疫组织化学因素卵巢上皮癌标本淋巴管内皮细胞抗体透明质酸受体(LYVE-1),血小板血管内皮细胞粘附分子CD31血管内皮生长因子(VEGF)和胸苷磷酸化酶(TP)在卵巢上皮癌理解转移的病理机制卵巢癌。在无进展和整体变量生存是评估。笨重的残留病手术后是最好的预后指标(P < 0.001)无进展和总生存期(P < 0.001)。淋巴管计数是统计学意义无进展的预后因素(P = 0.05)和总生存期(P = 0.04)。数对生存曲线没有影响。之间的相关性被发现淋巴和计数年龄、组织学亚型、菲戈阶段或残留疾病。在分析并不重要。在协助淋巴传播可能是重要的在卵巢癌转移,但需要其他生物因素一起采取行动,因为它没有清楚的预后意义。卵巢癌的传播并不发生主要通过血管或淋巴路线但通过直接腹腔内可能发生疾病传播。

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