Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

Basten GP; Duthie SJ; Pirie LVaughan NHill MHPowers HJ

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Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

机译：DNA标记的DNA的稳定性和灵敏度修复活动补充叶酸健康的志愿者。

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We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA stability in a cohort, which is not folate deficient. Preintervention, there was a significant inverse association between uracil misincorporation in lymphocyte DNA and red cell folate (P < 0.05). In contrast, there were no associations between folate status and DNA strand breakage, global DNA methylation or DNA base excision repair (measured as the capacity of the lymphocyte extract to repair 8-oxoGua ex vivo). Folate supplementation elicited a significant reduction in uracil misincorporation (P < 0.05), while DNA strand breakage and global DNA methylation remained unchanged. Increasing folate status significantly decreased the base excision repair capacity in those volunteers with the lowest preintervention folate status (P < 0.05). Uracil misincorporation was more sensitive to changes in folate status than other measures of DNA stability and therefore could be considered a specific and functional marker of folate status, which may also be relevant to cancer risk in healthy people.

机译：我们以前报道,补充与叶酸(每天1.2毫克(1)12周)引起了叶酸显著改善61名健康志愿者。这个补充的标记基因的影响稳定。叶酸补充DNA稳定队列,这不是叶酸缺乏。Preintervention,有一个明显的逆尿嘧啶之间的关联错误插入淋巴细胞DNA和红细胞叶酸(P < 0.05)。相反,没有关系叶酸状态和DNA链断裂,全球的DNA甲基化或DNA碱基切除修复(测量淋巴细胞提取的能力修复8-oxoGua体外)。引起显著减少尿嘧啶错误插入(P < 0.05),而DNA链破损和全球DNA甲基化不变。基本切除修复能力下降这些志愿者preintervention最低的叶酸状态(P < 0.05)。叶酸状况的变化更敏感比其他的DNA稳定性和措施因此可以被认为是一个特定的和功能标记的叶酸状态,这可能有关健康的癌症风险人。

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来源
《The British journal of cancer》 |2006年第12期|1942-1947|共6页
作者
Basten GP; Duthie SJ; Pirie LVaughan NHill MHPowers HJ;
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作者单位

Human Nutrition Unit, Division of Clinical Sciences (North), The University of Sheffield, Northern General Hospital, UK.;

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正文语种英语
中图分类肿瘤学;
关键词
folic acid supplementation; DNA stability; DNA Strand BreakFolateUracilDietary SupplementsHealthy VolunteersDNA RepairDNABase Excision RepairBiological MarkersDNA MethylationVitamin B ComplexFolic Acid;

机译：叶酸;DNA稳定性;DNASupplementsHealthy VolunteersDNA RepairDNABase切除RepairBiological MarkersDNAMethylationVitamin B ComplexFolic酸;

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Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

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