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首页> 外文期刊>The British journal of cancer >Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.
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Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.

机译：蛞蝓表达式是一个独立的预后参数为贫困生存在结直肠癌的病人。

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摘要

Slug, a member of the Snail family of transcription factors, plays a crucial role in the regulation of epithelial-mesenchymal transition (EMT) by suppressing several epithelial markers and adhesion molecules including E-cadherin. Recently, several studies have reported Slug to be expressed in breast carcinoma, oesophageal carcinoma accompanied with shorter survival. In this study, we first investigated expression of Slug mRNA in five colorectal carcinoma cell lines by reverse transcription-polymerase chain reaction. Furthermore, we investigated Slug and E-cadherin expression by immunohistochemistry in 138 patients with colorectal carcinoma. Slug mRNA was clearly expressed in four out of five colorectal carcinoma cell lines. Positive expression of Slug and E-cadherin was observed in 37 and 58% of cases, respectively. The positive expression of Slug was significantly associated with Dukes stage and distant metastasis (P = 0.0027 and 0.0007), and the positive expression of Slug had a significant impact onpatient overall survival (P < 0.0001, log-rank test). Moreover, patients with positive expression of Slug and reduced expression of E-cadherin showed the worst prognosis (P < 0.0001, log-rank test). Multivariate analysis indicated that Slug expression was an independent prognostic factor. These results suggest that positive Slug expression in colorectal carcinoma patients may become a significant parameter of poor prognosis.
机译：鼻涕虫、蜗牛家族的一员转录因子,起着至关重要的作用epithelial-mesenchymal的规定过渡(EMT)通过抑制一些上皮细胞标记和粘附分子包括钙粘蛋白。报道蛞蝓表达在乳腺癌癌,食管癌伴随着较短的生存。调查在五个蛞蝓mRNA的表达通过反向结直肠癌细胞系聚合酶链反应。此外,我们研究了弹头和钙粘蛋白138年由免疫组织化学表达结直肠癌患者。明确表示在四个五结直肠癌细胞系。和钙粘蛋白在37和58%的情况下,分别。鼻涕虫与公爵显著相关阶段和远处转移(P = 0.00270.0007),和蛞蝓的积极表现onpatient总体生存产生重大影响生存率较(P < 0.0001)。积极表达的蛞蝓和减少钙粘蛋白的表达了最坏的打算生存率较预后(P < 0.0001)。多变量分析表明,蛞蝓表达式是一个独立的预后因素。这些结果表明,积极的鼻涕虫表达式在结直肠癌患者成为不良预后的一个重要参数。

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