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首页> 外文期刊>The British journal of cancer >COSMIC 2005.
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COSMIC 2005.

机译：2005年宇宙。

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The Catalogue Of Somatic Mutations In Cancer (COSMIC) database and web site was developed to preserve somatic mutation data and share it with the community. Over the past 25 years, approximately 350 cancer genes have been identified, of which 311 are somatically mutated. COSMIC has been expanded and now holds data previously reported in the scientific literature for 28 known cancer genes. In addition, there is data from the systematic sequencing of 518 protein kinase genes. The total gene count in COSMIC stands at 538; 25 have a mutation frequency above 5% in one or more tumour type, no mutations were found in 333 genes and 180 are rarely mutated with frequencies <5% in any tumour set. The COSMIC web site has been expanded to give more views and summaries of the data and provide faster query routes and downloads. In addition, there is a new section describing mutations found through a screen of known cancer genes in 728 cancer cell lines including the NCI-60 set of cancer cell lines.
机译：体细胞突变在癌症的目录(宇宙)数据库和网站开发保存体细胞突变和分享数据社区。大约有350癌症基因确定,其中311是不良变异。宇宙已经扩大,保存数据之前报道的科学文献28已知的癌症基因。从518年的测序数据蛋白激酶基因。宇宙站在538;频率超过5%在一个或多个肿瘤类型,没有基因突变被发现在333年和180年很少在任何肿瘤突变频率< 5%集。提供更多的数据和观点和总结提供更快的查询路线和下载。另外,有一个新的部分描述通过屏幕上已知的癌症突变的发现728年癌症细胞系包括基因NCI-60癌症细胞系。

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