...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of cancer >Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2.
【24h】

Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2.

机译：肿瘤萌芽在最深的入侵与淋巴结转移有关粘膜下层的大肠癌检测到anticytokeratin抗体CAM5.2。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the past few years, tumour budding at the invasive margin has been reported as a new risk factor for lymph node metastasis in advanced colorectal cancers, but it is sometimes difficult to detect tumour budding in submucosal colorectal cancer by haematoxylin and eosin staining. We immunohistochemically examined tumour budding at the deepest invasive margin of 56 surgically resected submucosal colorectal carcinomas using anticytokeratin antibody CAM5.2, furthermore checked by AE1/AE3, and determined the relation between tumour budding and clinicopathological factors. Moreover, we used the monoclonal antibody D2-40 for immunohistochemistry to detect lymphatic involvement. Tumour budding was detected in 42 cases (75.0%), and the budding-positive group showed a significantly higher rate of lymph node metastasis (including isolated tumour cells) (16/42 vs 0/14; P=0.004) than the budding-negative group. The sensitivity and negative predictive value of tumour budding alone for lymph node metastasis were superior to those of lymphatic invasion alone. Furthermore, the specificity and positive predictive value of the combination of either lymphatic invasion or tumour budding were superior to those of lymphatic invasion alone. Tumour budding detected immunohistochemically by using CAM5.2 is a newly found risk factor for lymph node metastasis and may help to avoid oversurgery in the future.
机译：在过去的几年中,肿瘤的萌芽入侵已被报告为一个新的风险因素在先进的淋巴结转移结肠直肠癌,但它有时是困难的检测在黏膜下结直肠肿瘤出芽癌症被苏木精和伊红染色。免疫组织化学检查肿瘤出芽最深的侵入性的56个手术切除结肠直肠黏膜下癌anticytokeratin抗体CAM5.2,此外由AE1 / AE3检查,确定关系肿瘤出芽和临床病理之间的关系的因素。抗体D2-40免疫组织化学检测淋巴参与。检测到42例(75.0%),budding-positive组显著显示淋巴结转移率(包括高孤立的肿瘤细胞)(16/42和0/14;比budding-negative组。和消极的预测价值的肿瘤出芽淋巴结转移是优于独自上路淋巴的入侵。的特异性和阳性预测值或淋巴入侵的结合肿瘤出芽是优越的淋巴入侵。免疫组织化学利用CAM5.2新发现淋巴结转移和风险因素在未来可能有助于避免oversurgery。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号