Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.

Hiraoka K; Miyamoto M; Cho YSuzuoki MOshikiri TNakakubo YItoh TOhbuchi TKondo SKatoh H

首页> 外文期刊>The British journal of cancer >Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.

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Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.

机译：并发渗透的CD8 + T细胞和CD4 + T细胞是一个有利的预后因素非小细胞肺癌。

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The purpose of this study was to clarify the relationship between the number of tumour-infiltrating T lymphocytes and the clinicopathological features and clinical outcome in patients with non-small-cell lung cancer (NSCLC). Tissue specimens from 109 patients who underwent surgical resection for NSCLC were immunohistochemically analysed for CD4 and CD8 expression. Patients were classified into two groups according to whether their tumours exhibited a 'high' or 'low' level of CD8(+) or CD4(+) lymphocyte infiltration. Although the level of infiltration by CD8(+) T cells alone had no prognostic significance, the survival rate for patients with both 'high' CD8(+) and 'high' CD4(+) T-cell infiltration was significantly higher than that for the other groups (log-rank test, P=0.006). Multivariate analysis indicated that concomitant high CD8(+) and high CD4(+) T-cell infiltration was an independent favourable prognostic factor (P=0.0092). In conclusion, the presence of high levels of both CD8(+) T cells and CD4(+) T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.

机译：本研究的目的是明确的的数量之间的关系tumour-infiltrating T淋巴细胞和临床病理特征和临床结果在非小细胞肺癌患者(NSCLC)。接受手术切除的非小细胞肺癌免疫组织化学分析CD4和CD8表达式。组织根据他们的肿瘤表现出“高”或“低”的CD8(+)或水平CD4(+)淋巴细胞浸润。水平仅靠CD8 (+) T细胞浸润没有预后意义,存活率患者CD8(+)“高”和“高”CD4 (+) t细胞浸润明显高于其他组(log-rank测试中,P = 0.006)。伴随高CD8(+)和高CD4 (+)t细胞浸润是一个独立的优惠预后因素(P = 0.0092)。存在的高水平的CD8 (+) T细胞和CD4 (+) T细胞的一个重要指标更好的与非小细胞肺癌患者的预后这些细胞群之间的合作允许一个更强有力的抗肿瘤反应比人口。

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来源
《The British journal of cancer》 |2006年第2期|275-280|共6页
作者
Hiraoka K; Miyamoto M; Cho YSuzuoki MOshikiri TNakakubo YItoh TOhbuchi TKondo SKatoh H;
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作者单位

Surgical Oncology, Cancer Medicine, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan. hiraoka@ucla.edu;

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正文语种英语
中图分类肿瘤学;
关键词
Non-Small-Cell Lung Carcinoma; infiltration; CD4 Positive T LymphocytesGood prognosisT-LymphocytesCD4 AntigensCD8-Positive T-LymphocytesCD8 antigenPrognostic FactorsCarcinoma;

机译：非小细胞肺癌;渗透;CD4细胞+ T LymphocytesGoodprognosisT-LymphocytesCD4 AntigensCD8-PositiveT-LymphocytesCD8 antigenPrognosticFactorsCarcinoma;

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3. Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱 [J] . Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第18期

机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱
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Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.

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