...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EMBO Journal >Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs
【24h】

Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs

机译：乙酰化作用的GATA-3影响t细胞生存和导航二级淋巴器官

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acetylation of a transcription factor has recently been shown to play a significant role in gene regulation. Here we show that GATA-3 is acetylated in T cells and that a mutation introduced into amino acids 305-307 (KRR-GATA3) creates local hypoacetylation in GATA-3. Remarkably, KRR-GATA3 possesses the most potent suppressive effect when compared with other mutants that are disrupted in putative acetylation targets. Expressing this mutant in peripheral T cells results in defective T-cell homing to systemic lymphnodes, and prolonged T-cell survival after activation. These findings have significant implications in that the acetylation state of GATA-3 affects its physiological function in the immune system and, more importantly, provides evidence for the novel role of GATA-3 in T-cell survival and homing to secondary lymphoid organs. [References: 56]
机译：乙酰化作用的转录因子在基因发挥重要作用监管。乙酰化在T细胞突变305 - 307年引入氨基酸(KRR-GATA3)创建本地hypoacetylation GATA-3。值得注意的是,KRR-GATA3拥有最强大的相比与其他抑制的影响突变体,在假定的中断乙酰化的目标。周边T细胞导致T细胞缺陷系统性lymphnodes归航,延长了t细胞活化后生存。产生重大影响的乙酰化GATA-3影响它的状态在免疫系统的生理功能,更重要的是,为小说提供了证据GATA-3在t细胞生存和导航的作用二级淋巴器官。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号