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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Biological correlates of FDG uptake in non-small cell lung cancer.
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Biological correlates of FDG uptake in non-small cell lung cancer.

机译：氟- 18 -去氧葡萄糖摄取的生物相关非小细胞肺癌。

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摘要

PURPOSE: Each pathological stage of non-small cell lung cancer (NSCLC) consists of a heterogeneous population containing patients at much higher risk than others. Noninvasive functional imaging modalities, such as 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), could play a role in further characterization of NSCLCs. As many factors can influence the extent of FDG uptake, the underlying mechanisms for FDG accumulation in tumors, are still a matter of debate. The aim of the present study was to investigate these possible mechanisms in the primary site of early stage preoperatively untreated NSCLC. METHODS: 19 patients with early stage NSCLC, who had undergone both preoperative FDG-PET imaging and curative surgery, were enrolled in this study. Standardized uptake values (SUVs) were used for evaluation of primary tumor FDG uptake. Final diagnosis, tumor type, tumor cell differentiation and size of the primary tumors were confirmed histopathologically in resected specimens. Histologic sections were analyzed for amount of inflammation and necrosis. Expression of the glucose membrane transporters (GLUT-1 and GLUT-3); the isoforms of the glycolytic enzyme hexokinase (HK-I, HK-II and HK-III); and the cysteine protease caspase-3, was evaluated immunohistochemically. RESULTS: FDG uptake was significantly higher in squamous cell carcinomas (mean SUV 13.4+/-4.9, n=8) compared to adenocarcinomas (7.1+/-3.3, n=8, p=0.007), or large cell carcinomas (5.9+/-1.9, n=3, p=0.02). The degree of FDG accumulation seemed to depend especially on GLUT-1, GLUT-3 and tumor cell differentiation. The summed standardized values of these three parameters correlated significantly with the SUV (r=0.47, p=0.05). CONCLUSION: The present study supports the hypothesis that tumor cell differentiation in combination with overexpression of GLUT-1 and GLUT-3 determine the extent of FDG accumulation and that squamous cell carcinomas accumulate more FDG than adenocarcinomas or large cell carcinomas.
机译：目的:每个非小细胞的病理阶段肺癌(NSCLC)由一个异类人口包含病人高得多比其他的风险。形式,例如18 f-fluorodeoxyglucose正电子发射断层扫描(正)发挥作用的进一步描述非小细胞肺癌。氟- 18 -去氧葡萄糖摄取的,底层FDG的机制积累在肿瘤中,仍然是一个问题辩论。调查这些可能的机制术前主站点的早期阶段未经治疗的非小细胞肺癌。期非小细胞肺癌,他经历了术前摄影成像和治疗手术治疗参加本研究。值(suv)被用于评价初选氟- 18 -去氧葡萄糖摄取肿瘤。肿瘤的细胞分化和大小原发性肿瘤组织病理学证实在切除标本。分析大量的炎症和坏死。葡萄糖膜转运蛋白的表达(GLUT-1和GLUT-3);糖酵解酶己糖激酶(HK-I HK-II和HK-III);评估免疫组织化学。吸收明显高于鳞状细胞癌(平均SUV 13.4 + / - -4.9, n = 8)相比腺癌(7.1 + / - -3.3,n = 8, p = 0.007),或大细胞癌(5.9 + / - -1.9,n = 3, p = 0.02)。FDG积累似乎依赖的程度特别是在GLUT-1, GLUT-3和肿瘤细胞分化。这三个参数相关显著的SUV (r = 0.47, p = 0.05)。结论:本研究支持假设肿瘤细胞分化结合GLUT-1和超表达GLUT-3确定FDG积累的程度鳞状细胞癌积累更多FDG比腺癌和大细胞癌。

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