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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Clinical significance of a solitary ground-glass opacity (GGO) lesion of the lung detected by chest CT.
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Clinical significance of a solitary ground-glass opacity (GGO) lesion of the lung detected by chest CT.

机译：一个孤独的毛玻璃的临床意义不透明度(GGO)病变的肺检测到胸部CT。

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Ground-glass opacity (GGO) attracts attention because of the possibility of early lung cancer. However, some lesions are reduced in size or disappear at follow-up. This study was designed to explore the natural history of solitary GGO, to determine the prevalence of malignancy and to identify factors predictive of benignity or malignancy. Solitary and focal GGO lesions [pGGO (p=pure) and mGGO (m=mixed) based on the presence of a solid component] of less than 3 cm were included. Lesions of less than 1cm were followed up by chest HRCT 3 months later and lesions over 1cm were investigated by percutaneous needle biopsy (PCNB). One hundred and eighty-six patients (69 pGGO and 117 mGGO) were enrolled. Of the 69 pGGO lesions, 7 were diagnosed as pre-malignant or malignant lesions, 3 as benign lesions and 26 pGGO lesions (37.6%) were reduced or disappeared (transient lesions) at follow-up chest HRCT. The other 33 lesions showed no significant change during follow-up. Thus, the probability of malignancy in pGGOwas 7/36 (19.4%). On the other hand, of the 117 mGGO lesions, 26 were found to be malignant, 3 were diagnosed as benign and 57 lesions (48.7%) were reduced or had disappeared at follow-up chest HRCT. The other 31 lesions showed no change during follow-up, and thus the probability of malignancy in mGGO was 26/86 (30.2%). A female sex and a spiculated mGGO border were found to be related with malignancy. However, a high blood eosinophil count was strongly associated with regressing or transient mGGO, suggesting that pulmonary infiltrate with eosinophilia (PIE) might have been responsible. We recommend short-term follow-up by chest HRCT be conducted for mGGO lesions in the presence of high eosinophilia--regardless of lesion size.
机译：毛玻璃样阴影(GGO)吸引了注意力因为早期肺癌的可能性。然而,一些病变在大小或减少在随访消失。探索单独GGO的自然历史,确定恶性肿瘤的患病率和确定预测的仁慈或的因素恶性肿瘤。(p =纯)和mGGO (m =混合)基础上的存在固体组件)小于3厘米包括在内。由胸部HRCT 3个月后,病变通过经皮针1厘米了活组织检查(PCNB)。患者(69 pGGO和117 mGGO)登记。69年pGGO病变7被诊断为3、恶性病变,3为良性病变和26 pGGO病变(37.6%)降低在后续或消失(瞬态损伤)胸部HRCT。在后续的重大变化。恶性肿瘤在pGGOwas 7/36的概率(19.4%)。恶性病变,26日被发现,3诊断为良性和57个病灶(48.7%)减少或消失在随访的胸膛HRCT。在随访中,这样的概率恶性肿瘤在mGGO 26/86(30.2%)。性和一个尖锐的mGGO边境被发现与恶性肿瘤有关。嗜酸性粒细胞计数是密切相关的回归或短暂mGGO,暗示肺嗜酸性粒细胞浸润而(派)可能是负责任的。通过胸部HRCT进行短期随访在存在高mGGO病变嗜酸性粒细胞——不管病灶大小。

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