...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Evaluation of extratumoral lymphatic permeation in non-small cell lung cancer as a means of predicting outcome.
【24h】

Evaluation of extratumoral lymphatic permeation in non-small cell lung cancer as a means of predicting outcome.

机译：评价extratumoral淋巴渗透非小细胞肺癌的一种手段预测的结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Lymphatic permeation (ly) has been described as a potential prognostic factor for non-small cell lung cancer (NSCLC). METHODS: The purpose of this study was to analyze whether evaluation of the presence or absence of ly and its location (ly 0: absent, N=464; ly 1: intratumoral, N=42; ly 2: extratumoral, N=52) provides an appropriate means of predicting the outcome of NSCLC. We investigated the clinical implications of ly in 558 consecutive patients with surgically resected NSCLC. RESULTS: Evaluation according to ly status showed that the recurrence-free survival (RFS) time of the ly 2 patients was significantly shorter than that of the ly 0 patients (P<0.0001), the ly 1 patients (P=0.0028). A significant difference in RFS time was also observed between the ly 0 patients and the ly 1 patients (P=0.0025). RFS time of the ly 0 patients was significantly longer than that of the ly 1 plus ly 2 patients (P<0.0001). We also evaluated the patients with pathological stage I disease (N=378) separately. The RFS time of the ly 2 patients (N=9) was significantly shorter than that of the ly 0 plus ly 1 patients (P<0.0001). In the nine ly 2 patients, six developed a distant metastasis within 1 year. A multivariate analysis revealed that ly status (ly 0 plus ly 1 versus ly 2) was an independent prognostic factor (P=0.0116), demonstrating the significant prognostic value of extratumoral lymphatic permeation in NSCLC. CONCLUSIONS: These results indicate that ly status is a good prognostic marker of poorer outcome in patients with resected NSCLC.
机译：背景:淋巴渗透(ly)描述为一个潜在的预后因素非小细胞肺癌(NSCLC)。本研究的目的是分析是否ly的存在与否和评估它的位置(ly 0:缺席,N = 464;瘤内,N = 42;提供了一个适当的预测非小细胞肺癌的结果。影响558年ly连续的病人与手术切除的非小细胞肺癌。评估根据ly状态显示recurrence-free ly的生存(RFS)时间2患者明显短于ly 0例(P < 0.0001), ly 1病人(P = 0.0028)。ly 0之间也观察到病人和ly 1患者(P = 0.0025)。比0患者明显较长ly 1 + ly 2患者(P < 0.0001)。评估患者病理阶段单独的疾病(N = 378)。ly 2例(N = 9)明显缩短比ly 0 + ly 1病人(P < 0.0001)。开发了一个在1年内远处转移。多变量分析表明ly状态(ly0 + ly 1和ly 2)是一个独立的预后因素(P = 0.0116),展示了extratumoral的重要预后价值在非小细胞肺癌淋巴渗透。结果表明,供应是一个很好的状态患者预后的标志贫穷的结果切除非小细胞肺癌患者。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号