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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Genetic relationship among atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and adenocarcinoma of the lung.
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Genetic relationship among atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and adenocarcinoma of the lung.

机译：基因非典型腺瘤之间的关系支气管肺泡癌和增生肺腺癌。

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Atypical adenomatous hyperplasia (AAH) has been recently defined by WHO as a small lesion, not exceeding 5mm in major axis, composed of slightly enlarged alveolar septa lined by pneumocytes with plump, atypical nuclei. AAH is frequently found in tissue surrounding lung adenocarcinoma and is considered a precursor of this subtype of lung cancer by many Authors. However, the genetic relationship between adenocarcinoma and the associated foci of AAH is not well defined. In particular, it is not clear whether multiple foci of AAH and of adenocarcinoma in the same patients are clonally related to each other or represent independent neoplastic foci. To clarify if AAH and the associated cancer are clonally related, we evaluated the genetic distance between these two lesions in 16 patients, using direct sequencing of mitochondrial DNA (D-loop region). Furthermore, LOH analysis for 7 microsatellites (D3S1478 at 3p21, D3S1300 at 3p14.2, D9S942 at 9p21, D5S346 at 5q21, D17S261 at 17p13.1, D18S46 at 18q21, D19S246at 19q13.2) was also performed. Our results indicate that, in at least 9 out of 13 informative cases (69.2%), AAH and the associated cancer were not clonally related as they showed a different mutation pattern in the mitochondrial D-loop region. These findings were also in agreement with the LOH data which showed losses in different loci in at least three cases. On the contrary an identical LOH pattern between BAC and AAH was found in one case. Similar but not identical LOH pattern between AAH and related tumors was found in other three cases. Therefore, our results suggest that AAH and the associated cancer are genetically independent in agreement with the concept of cancerization field. Less frequently AAH foci could represent an early spread of cells from the main tumor, rather than a precursor lesion.
机译：非典型腺瘤性增生(啊)最近由世界卫生组织定义为一个小的病变,不是超过5毫米轴,主要组成的扩大pneumocytes肺泡隔排列的丰满,非典型细胞核。在肺腺癌,周围组织肺的先兆的亚型癌症被许多作者。腺癌和之间的关系相关的焦点啊不是良好定义的。目前尚不清楚是否有多个病灶啊和腺癌在同一病人无性繁殖系地相互关联或代表什么独立的肿瘤病灶。和相关的癌症是无性生殖相关的,我们评估这些之间的遗传距离两个16例患者病变,直接使用线粒体DNA测序(D-loop地区)。此外,LOH分析7个微卫星(D3S1478 3 p21, D3S1300 3 p14.2 D9S9425点9 p21, D5S346对方篮里,D17S261 17 p13.1 D18S4618岁时,对方篮里D19S246at 19 q13.2)也执行。我们的研究结果表明,至少在913的例(69.2%),啊相关癌症没有无性生殖他们显示不同的突变模式线粒体D-loop地区。也同意LOH数据显示损失在不同的位点在至少三个病例。相反一个相同的LOH模式之间在一个案例中发现了BAC和啊。不相同的LOH啊和相关之间的模式肿瘤被发现在其他三个案例。我们的研究结果表明,啊和相关的癌症是基因独立的协议与癌化领域的概念。经常啊焦点可能是早期肿瘤细胞扩散的主要,而不是前体病变。

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