The elderly with synchronous non-small cell lung cancer and solitary brain metastasis: does palliative thoracic radiotherapy have a useful role?

Ampil F; Caldito G; Milligan SMills GNanda A

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The elderly with synchronous non-small cell lung cancer and solitary brain metastasis: does palliative thoracic radiotherapy have a useful role?

机译：老年人与同步非小细胞肺癌癌症和孤独的脑转移:胸姑息放疗有有用角色?

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We evaluated the prognosis associated with advanced age by comparing the clinical features of individuals 65 years of age and older to those of younger patients with single metastasis to the brain alone (SMBA) and simultaneous non-small cell lung cancer (NSCLC), and the potential role of palliative thoracic radiotherapy in this cohort of patients. Our 23-year experience included 72 consecutive (22 elderly and 50 non-elderly) people. Older patients predominantly presented with N0-N1 stage disease and coexisting illness. Univariate analysis showed that younger age (p=0.04) and operative removal of SMBA (p=0.01) were predictive of better survival. However, with multivariate analysis, resection of SMBA remained the sole predictor of prognosis. The application of NSCLC radiotherapy for palliation did not favorably alter outcome. In conclusion, elderly patients with simultaneous NSCLC and SMBA seem to fare less well than their younger counterparts. Moreover, the concurrent application of radiotherapy for palliation of the lung neoplasm was not prognostically advantageous.

机译：我们评估相关的预后先进的年龄进行比较的临床特征个人的65岁及以上的人年轻患者单一转移同时大脑独自(SMBA)和非小细胞性肺癌(NSCLC)和潜在的作用的胸姑息性放疗群病人。包括72名连续(22老年人和50费用)人。面对N0-N1阶段疾病和共存疾病。年龄(p = 0.04)和手术切除SMBA(p = 0.01)预测更好的生存。然而,多变量分析,切除SMBA保持唯一的预后预测指标。非小细胞肺癌放射治疗中的应用减轻不积极改变的结果。结论老年患者同时进行非小细胞肺癌和SMBA似乎比他们表现不佳年轻的同行。应用放疗的辩解肺肿瘤并不是影响预后有利。

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《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2007年第1期|60-65|共6页
作者
Ampil F; Caldito G; Milligan SMills GNanda A;
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作者单位

Department of Radiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. fampil@lsuhsc.edu;

Department of Materials Science and Engineering, North Carolina State University, Raleigh, NC 27695, U. S. A;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Non-Small-Cell Lung Carcinoma; control symptoms; aged personRadiotherapyMetastatic Malignant Neoplasm to the BrainPrognosticLung Neoplasms;

机译：非小细胞肺癌;控制岁personRadiotherapyMetastatic症状;BrainPrognosticLung恶性肿瘤肿瘤;

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The elderly with synchronous non-small cell lung cancer and solitary brain metastasis: does palliative thoracic radiotherapy have a useful role?

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