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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Defective expression of transforming growth factor beta type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma.
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Defective expression of transforming growth factor beta type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma.

机译：有缺陷的转化生长因子的表达β2型受体(TGFBR2)大细胞非小细胞肺癌的变体。

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摘要

Large cell carcinoma (LCC) of the lung is defined as an undifferentiated carcinoma without the characteristic features of squamous cell (SqC), small cell, or adenocarcinomas (AdC). In the present study, the expression level of the important tumor suppressor, transforming growth factor beta type II receptor (TGFBR2), was examined both in LCC and non-LCC tumors, which include AdC, SqC and adenosquamous carcinoma (Ad-SqC). Immunohistochemical staining with TGFBR2 antibody revealed statistically significant or near significant differences in the reduced expression in LCC (80% of cases) versus AdC (42.1% of cases, P=0.0288) and SqC (47.1% of cases, P=0.0589), or LCC versus non-LCC (45% of cases, P=0.02). The differences in the expression level of TGFBR2 between LCC and non-LCC were consistent with the histopathologic classification of these tumors, suggesting that the defective TGFBR2 expression might contribute to the carcinogenesis and/or development of LCC.
机译：肺大细胞癌(LCC)的定义作为一个未分化癌没有鳞状细胞的特征(SqC),小细胞,或腺癌(AdC)。本研究的表达水平重要的肿瘤抑制,改变经济增长因子β2型受体(TGFBR2)检查在LCC non-LCC肿瘤,包括AdC, SqC和adenosquamous癌(Ad-SqC)。TGFBR2抗体显示统计重要的或接近显著差异减少表达LCC(80%的病例)与AdC(42.1%的情况下,P = 0.0288)和SqC(47.1%的情况下,P = 0.0589),或LCC与non-LCC(45%的情况下,P = 0.02)。表达水平之间的TGFBR2 LCC和与病理non-LCC是一致的这些肿瘤的分类,说明缺陷TGFBR2表达式可能的贡献致癌作用和/或低成本航空的发展。

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