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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
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Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.

机译：在cisplatin-induced k - ras基因点突变的基因/ J小鼠肺肿瘤。

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摘要

The risks of secondary lung cancer in patients with early stage non-small and small cell lung cancers are estimated to be 1-2% and 2-10% per patient per year, respectively. Surprisingly, the incidence of second primary cancer in locally advanced non-small cell lung cancer at 10 years, following cisplatin-based chemotherapy with concurrent radiotherapy, increases to 61%. Those patients, on the road to being cured, cannot overlook the possibility of developing a second primary cancer. We developed a second primary lung cancer model using cisplatin as a carcinogen in A/J mice to screen for chemopreventive agents for a second malignancy. In the primary lung tumour model, 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo(a)pyrene (BaP), urethane induces specific K-ras mutations in codon 12, codon 12, and codon 61, respectively, in the A/J mice. In this study, we investigated the mechanisms of carcinogenicity by cisplatin in the A/J mice. In the cisplatin-induced tumours, we found no K-ras codon 12 mutation, which is the major mutation induced by NNK or BaP. K-ras gene mutations in codon 13 and codon 61 were found in one tumour (4%) and five tumours (17.8%), respectively. These findings suggest that cisplatin is partially related to K-ras codon 61 mutations, and that the mechanism of carcinogenicity by cisplatin is different from that by NNK or BaP.
机译：二级肺癌病人的风险早期非小和小细胞肺癌癌症是估计为1 - 2%,2 - 10%病人每年,分别。在本地的第二个主要癌症发病率先进的非小细胞肺癌10年,cisplatin-based化疗后与并发放射治疗,增加到61%。病人,在路上被治愈,不能忽略第二个发展的可能性主要的癌症。肺癌模型使用顺铂作为致癌物在屏幕/ J小鼠chemopreventive代理第二恶性肿瘤。肿瘤模型,(4) - methyl-nitrosamino 1 - (3-pyridyl) 1-butanone密码子12 k - ras基因特定的密码子的突变12日,和密码子61年,分别在/ J小鼠。这项研究中,我们调查的机制致癌性的顺铂/ J小鼠。k - ras基因cisplatin-induced肿瘤,我们没有发现12密码子突变,这是主要的变异引起亚硝胺或软面包卷。密码子13密码子61被发现在一个肿瘤(4%)和五个肿瘤(17.8%),分别为。这些发现表明,顺铂部分与61 k - ras基因密码子突变有关,致癌性的机制顺铂不同于亚硝胺或软面包卷。

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