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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Maspin nuclear localization is linked to favorable morphological features in pulmonary adenocarcinoma.
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Maspin nuclear localization is linked to favorable morphological features in pulmonary adenocarcinoma.

机译：Maspin核本地化与有利在肺形态学特征腺癌。

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摘要

Maspin, a mammary homologue of Serine Protease Inhibitors, has been shown to inhibit tumor progression and metastasis. Recently, its biological functions have been linked to its subcellular localization. Specifically, a nuclear, opposed to a combined nuclear and cytoplasmic localization has been associated with increased survival in human malignancies, including non-small cell lung cancer (NSCLC). However, it is not known whether transformation affects maspin expression during lung carcinogenesis, and whether its subcellular localization correlates with the morphological features of NSCLC. To address these questions, we studied maspin expression in a model of transformation of bronchial epithelial cells and in resected NSCLC. We found that decreased maspin accompanied chemical transformation of normal immortalized bronchial epithelial cells BEAS 2B. Immunohistochemistry revealed maspin expression to be virtually universal in NSCLC, occurring in 72/77 Adenocarcinoma (ACa), and 46/46 squamous cell carcinoma (SqCCa). SqCCa showed almost exclusively a combined nuclear-cytosolic stain. In contrast, nuclear maspin, but not combined nuclear-cytoplasmic maspin significantly correlated with low histological grade, lower proliferative rate, absence of invasion, and negative p53 stain in ACa. These data support the hypothesis that nuclear localization of maspin may stratify subtypes of NSCLC with favorable clinical-pathological features.
机译：Maspin,丝氨酸蛋白酶的乳腺同系物抑制剂,可以抑制肿瘤进展和转移。与它的生物功能亚细胞定位。核、核和反对细胞质定位有关增加生存在人类恶性肿瘤,包括非小细胞肺癌(NSCLC)。然而,尚不清楚是否转换影响maspin表达式在肺致癌作用,其亚细胞本地化与形态非小细胞肺癌的特性。研究maspin表达模型支气管上皮细胞转化在切除的非小细胞肺癌。伴随的化学转换正常不灭的支气管上皮细胞比阿斯2 b。免疫组织化学显示maspin表达式在非小细胞肺癌,几乎普遍发生腺癌(ACa), 72/77和46/46鳞状细胞癌(SqCCa)。专门联合nuclear-cytosolic污渍。相比之下,核maspin,但不是总和nuclear-cytoplasmic maspin显著与组织学评分低,低增殖率、缺乏入侵和- ACa p53污点。假设maspin核本地化分层亚型的非小细胞肺癌有利吗clinical-pathological特性。

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