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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study.
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Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study.

机译：在组织病理学诊断协议评价肺癌组织中以人群为基础的病例对照研究。

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摘要

Only few studies have compared the agreement of histological lung carcinoma diagnosis of a population-based case series and an independent pathology review. We analyzed data of our population-based lung cancer case-control study to determine the agreement in the histopathological evaluation of lung cancer. Six-hundred and sixty-eight out of 1004 interviewed male and female lung cancer cases were histologically evaluated according to the 1981 WHO classification by regional pathologists and a central pathologist who was blinded to the evaluations of the regional pathologists. The observed agreement was 0.65 with kappa = 0.54 (95% CI: 0.49-0.58). It was highest for small-cell carcinoma (0.94; kappa = 0.82) and lower for squamous-cell carcinoma (0.81; kappa = 0.58) and adenocarcinoma (0.81; kappa = 0.55). Agreement was slightly higher among women than men. The observed agreement among non-smoking cases was 58% as compared to 67% heavy smoking cases. The moderate agreement for squamous-cell and adenocarcinoma complicates epidemiological studies that address these histological subtypes.
机译：只有少数研究比较了协议的组织学诊断肺癌以人群为基础的病例系列和一个独立的病理学检查。基于人群的肺癌病例对照研究确定的协议组织病理学评价肺癌。六百年和六十八年的1004人采访了男性和女性的肺癌病例组织学评估的根据吗1981年世卫组织分类区域病理学家和一个中央病理学家被蒙蔽评价区域的病理学家。观察到的协议0.65 k = 0.54(95%置信区间:0.49—-0.58)。小细胞癌(0.94;鳞状细胞癌较低(0.81;0.58)和腺癌(0.81;女性略高于协议男人。情况下是58%比67%重吸烟用例。和腺癌复杂化的流行病学研究解决这些组织学亚型。

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