Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases.

Veronesi G; Morandi U; Alloisio MTerzi ACardillo GFilosso PRea FFacciolo FPelosi GGandini SCalabro FCasali CMarulli GSpaggiari L

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Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases.

机译：肺大细胞神经内分泌癌:一个回顾性分析144例手术病例。

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OBJECTIVE: Large cell neuroendocrine carcinoma of the lung are considered aggressive. However, reported prognoses are heterogeneous and the optimum treatment remains undefined. We retrospectively evaluated outcomes in a series of patients with a pathological diagnosis of large cell neuroendocrine lung carcinoma, who underwent lung resection. We also assessed the utility of chemotherapy in a small subgroup. PATIENTS AND METHODS: The clinical records of 144 consecutive patients were reviewed in a multicenter study. Survival times, assessed from the day of surgery until death or most recent follow-up, were estimated by the Kaplan-Meier method, and compared by the log rank test. RESULTS: There were 117 men and 27 women of median age 63 years. Twelve wedge resections, 3 segmentectomies, 95 lobectomies, 7 bilobectomies and 24 pneumonectomies were performed. Induction chemotherapy was given in 21 and postoperative chemotherapy in 24. Pathologically, 73 (50%) were stage I, 29 (20%) stage II, 40 (28%) stage IIIand 2 stage IV. Postoperative mortality was 2.8% and morbidity 26%. Overall 5-year survival was 42.5%: 52% for stage I, 59% for stage II and 20% for stage III (p=0.001 log-rank test on Kaplan-Meier curves). A trend to better outcome was associated with preoperative or postoperative chemotherapy in stage I disease (p=0.077) compared to no chemotherapy. The response rate to induction chemotherapy was 80% in the 15 patients with data available. CONCLUSION: large cell neuroendocrine carcinoma of the lung are confirmed as aggressive but are also chemosensitive. Our experience suggests that chemotherapy may improve prognosis in stage I disease.

机译：目的:大细胞神经内分泌癌肺被认为是积极的。报告预测是异构的最佳治疗仍是未定义的。在一系列的回顾性评估结果病理诊断的患者肺细胞神经内分泌癌,他接受了肺切除术。化疗在小群。方法:对临床144连续的记录综述了患者的多中心研究。天的生存时间,评估手术直到死亡或最近的后续kaplan meier估计的方法而通过日志等级测试。27 117名男性和女性的平均年龄63岁。十二个楔形切除术,3侧,95叶切除术,7 bilobectomies 24肺切除术进行。用21和术后化疗了化疗在24。阶段II阶段我,29例(20%),IIIand 40(28%)阶段2四期。术后死亡率为2.8%发病率26%。阶段II阶段我52%,59%和20%第三阶段(p = 0.001 kaplan meier生存率较曲线)。与术前或术后化疗在舞台上我病没有相比(p = 0.077)化疗。化疗患者80% 15的数据可用。癌确诊的肺都是咄咄逼人但也是敏感的。表明,化疗可以改善预后在舞台上我的疾病。

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来源
《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2006年第1期|111-115|共5页
作者
Veronesi G; Morandi U; Alloisio MTerzi ACardillo GFilosso PRea FFacciolo FPelosi GGandini SCalabro FCasali CMarulli GSpaggiari L;
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作者单位

Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. giulia.veronesi@ieo.it;

reventionsource.bc.ca;

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正文语种英语
中图分类肿瘤学;
关键词
Carcinoma of Lung; Lung; Induction ChemotherapyPneumonectomyDrug TherapyLarge Cell Neuroendocrine CarcinomaAntineoplastic AgentsPrognosisGrossNeoplasm StagingSurgery;

机译：癌的肺,肺;归纳ChemotherapyPneumonectomyDrug TherapyLarge细胞Neuroendocrine CarcinomaAntineoplastic;

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Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases.

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