• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Histone deacetylase 1 mRNA expression in lung cancer.
【24h】

Histone deacetylase 1 mRNA expression in lung cancer.

机译：组蛋白脱乙酰酶1在肺mRNA的表达癌症。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Histone deacetylases (HDACs) play a crucial role in tumorigenesis, however, the expression status of HDACs in lung cancer tissues has not been reported. We have investigated that HIDAC 1 mRNA levels and other clinico-pathological data, including MTA 1 mRNA expression in lung cancer. The study included 102 lung cancer cases. The HDAC1 mRNA levels were quantified by real time reverse transcription-polymerase chain reaction (RT-PCR) using LightCycler (Roche Molecular Biochemicals, Mannheim, Germany). The HDAC1/GAPDH mRNA levels were not significantly different in tumor tissues from lung cancer (30.654 +/- 33.047) and adjacent non-malignant lung tissues (18.953 +/- 56.176 , P = 0.1827). No significant difference in HDAC1/GAPDH mRNA levels was found among age, gender, and lymph node metastasis. The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). HDAC1/GAPDH mRNA levels were significantly higherin T3 or T4 lung carcinoma (54.326 +/- 127.018) than in T1 or T2 lung cancers (14.790 +/- 48.670, P = 0.1601). HDAC1/GAPDH mRNA levels were correlated with MTA1/GAPDH mRNA levels (y = 0.0106x + 2.5827 , P = 0.0352 ). HDAC1/GAPDH mRNA levels were also correlated with HDAC1 protein (P = 0.0484) expression by immunohistochemistry. Using the LightCycler RT-PCR assay, the HDAC1 gene expression might correlate with progression of lung cancers. However, further studies are needed to confirm the impact of HDAC1 for the molecular target of the lung cancer.
机译：组蛋白去乙酰酶抑制剂(hdac)发挥着至关重要的作用然而,在肿瘤发生,表达状态hdac在肺癌组织中没有报道。水平和其他二数据,包括在肺癌MTA 1 mRNA的表达。该研究包括102例肺癌病例。HDAC1 mRNA水平被实时量化逆转录-聚合酶链反应(rt - pcr)使用LightCycler(罗氏分子生化药剂,德国曼海姆)。信使rna水平没有显著差异从肺癌肿瘤组织(30.654 + / -33.047)和邻良性肺组织(18.953 + / - 56.176, P = 0.1827)。不同HDAC1 / GAPDH mRNA水平被发现在年龄、性别、和淋巴结转移。HDAC1 / GAPDH mRNA水平显著提高阶段III或IV肺癌(50.929 + / -120.433)比在I期肺癌(11.430 + / -25.611, P = 0.0472)。明显较T3和T4肺癌(54.326 + / - 127.018)比T1或T2肺癌症(14.790 + / - 48.670,P = 0.1601)。HDAC1 / GAPDH mRNA水平相关MTA1 / GAPDH mRNA水平(0.0106 y = x + 2.5827, P= 0.0352)。与HDAC1相关蛋白(P = 0.0484)通过免疫组织化学表达。LightCycler rt - pcr分析,HDAC1基因表达可能与进展肺癌。确认的HDAC1分子的影响肺癌的目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号