The value of prognostic factors in small cell lung cancer: results from a randomised multicenter study with minimum 5 year follow-up.

Bremnes RM; Sundstrom S; Aasebo UKaasa SHatlevoll RAamdal S

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The value of prognostic factors in small cell lung cancer: results from a randomised multicenter study with minimum 5 year follow-up.

机译：小细胞肺癌预后因素的价值癌症:结果从一个随机多中心至少5年随访研究。

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We have evaluated the prognostic value of 22 pretreatment attributes in 436 small cell lung cancer (SCLC) patients included in a prospective multicenter study with a minimum 5-year follow-up. Pretreatment clinical and laboratory parameters were registered. Possible prognostic factors were evaluated by univariate analysis (log rank test) and by the Cox multivariate regression model. In the univariate analysis of all patients, only age, nodal metastasis, and skin metastasis were not associated with survival. The multivariate Cox model identified gender, extent of disease, performance status (PS), weight loss, platelet count, LDH, and NSE as independent prognostic factors. In subset multivariate analyses according to extent of disease, we found haemoglobin level, PS, NSE, and total WBC as significant prognostic indicators for survival in limited-stage disease (LD-SCLC), while PS, weight loss, LDH, number of metastases, liver metastases, and brain metastases were identified as independent prognostic factors in extensive-stage disease (ED-SCLC). There was a significant correlation between serum LDH and NSE levels. In conclusion, gender, extent of disease, PS, weight loss, haemoglobin, WBC count, platelet count, LDH, and NSE were all found to be independent prognostic factors for SCLC survival. However, the prognostic value of these factors depends highly on whether all or subsets of SCLC patients are studied.

机译：我们有22的预后价值评估436年,小细胞肺癌预处理属性癌症患者(SCLC)包含在未来的最低5年的多中心研究随访。参数被注册。单变量分析因素进行评估考克斯(日志等级测试)和多元回归模型。所有的病人,只有年龄、淋巴结的转移皮肤转移并不相关生存。性别、疾病的严重程度、性能状态(PS)、体重减轻、血小板计数,LDH,了无作为独立的预后因素。多元分析的程度疾病,我们发现血红蛋白水平、PS、了无总白细胞作为重要的预后指标为生存局限阶段疾病(LD-SCLC),在PS、体重减轻、LDH、转移,肝转移、脑转移确认为独立的预后因素extensive-stage疾病(ED-SCLC)。血清LDH和分析了无之间显著相关的水平。PS、体重减轻、血红蛋白、白细胞计数、血小板数、LDH和研究都发现SCLC生存的独立预后因素。然而,这些因素的预后价值高度取决于是否全部或SCLC的子集患者进行了研究。

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来源
《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2003年第3期|303-313|共11页
作者
Bremnes RM; Sundstrom S; Aasebo UKaasa SHatlevoll RAamdal S;
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作者单位

Department Oncology, University Hospital of Tromso, N-9038, Tromso, Norway. roy.bremnes@unn.no;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Small Cell Lung Carcinoma; Multicenter Study; serum lactate dehydrogenaseunivariate analysisPrognostic FactorsLung NeoplasmsCarcinomaMetastatic Malignant Neoplasm to the Skin;

机译：小细胞肺癌;多中心研究;血清乳酸dehydrogenaseunivariateanalysisPrognostic FactorsLungNeoplasmsCarcinomaMetastatic恶性肿瘤在皮肤上;

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机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱
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The value of prognostic factors in small cell lung cancer: results from a randomised multicenter study with minimum 5 year follow-up.

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