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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Dramatic effect of ZD1839 ('Iressa') in a patient with advanced non-small-cell lung cancer and poor performance status.
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Dramatic effect of ZD1839 ('Iressa') in a patient with advanced non-small-cell lung cancer and poor performance status.

机译：戏剧化的效果ZD1839(“艾瑞莎”)在一个病人晚期非小细胞肺癌和贫穷性能状态。

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We describe the case of a 52-year-old Japanese woman with advanced adenocarcinoma of the lung, in whom once-daily treatment with 250 mg ZD1839 ('Iressa') demonstrated a marked antitumour effect. She had initially achieved a partial response with cisplatin-based combination chemotherapy, but had subsequently progressed and had failed to respond to salvage chemotherapy. She had also received whole-brain irradiation for brain metastases. On admission, the patient was confined to bed due to dyspnoea and had rapidly progressing hypoxia secondary to lymphangitis carcinomatosa and a massive right pleural effusion. She was treated with oxygen supplementation and oral ZD1839, which, within a week, led to marked tumour regression and gradually improving dyspnoea. The main adverse event observed was a grade 2 rash. A month after starting ZD1839 treatment, the patient was discharged without the need for oxygen supplementation and had since returned to full-time work. This is a demonstration of ZD1839 producing a dramatic clinical response when administered to a patient with poor performance status who had received extensive prior treatment with cytotoxic agents.'Iressa' is a trademark of the AstraZeneca group of companies.
机译：我们描述一个52岁的日本人女人晚期肺腺癌,在他每天换一次250毫克ZD1839治疗(“艾瑞莎”)表现出显著的抗肿瘤的效果。响应与cisplatin-based组合化疗,但随后的进展未能应对救助化疗。她也收到了全脑照射脑转移。局限于床由于呼吸困难和迅速进步缺氧二级淋巴管炎carcinomatosa和右胸膜积液。补充和口头ZD1839,内上周,导致肿瘤回归和标记逐步改善呼吸困难。事件观察到的是一个二年级的皮疹。开始ZD1839治疗,病人排放不需要氧气补充,因为返回全职工作。生产一个戏剧性的临床反应让病人服用性能不佳状态之前收到了广泛的治疗与细胞毒性药物。阿斯利康集团公司。

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