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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >A short radiotherapy course for locally advanced non-small cell lung cancer (NSCLC): effective palliation and patients' convenience.
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A short radiotherapy course for locally advanced non-small cell lung cancer (NSCLC): effective palliation and patients' convenience.

机译：一个简短的放射治疗局部晚期非小细胞肺癌(NSCLC):有效缓解和病人的方便。

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In order to facilitate patients with symptomatic locally advanced NSCLC, especially those coming from remote areas we have employed two palliative RT schedules. The first (S1) is the well known from Medical Research Council (MRC) randomized studies 2 x 8.5 Gy one week apart and the second (S2) is a two-day RT schedule: three fractions of 4.25 Gy are given on the first day and two fractions of 4.25 Gy on the second day. The records of 92 patients were reviewed (48 for S1 and 44 for S2). Patients, disease characteristics and results were similar for both groups; rates of symptom disappearance were for S1 and S2, respectively: cough 24 and 20%, hemoptysis 60 and 67%, chest pain 57 and 64% and dyspnoea 55 and 45% The overall condition improved in 39 and 36%, respectively. The median palliation time in days was in S1 and S2, respectively: cough 70 and 66, haemoptysis 133 and 139, chest pain 68 and 62 and dyspnoea 74 and 69 days. The median survival was 25 weeks in both S1 and S2 groups (P=0.89 log-rank test). At 52 weeks (one year), ten (21%) and seven (16%) of the patients were alive in S1 and S2 groups, respectively. At 104 weeks, the corresponding figures were two (4%) and two (4.7%) for S1 and S2. Our results are in accordance to those reported in literature regarding the safety and efficacy of palliative hypofractionated radiotherapy schemes. Their use in selected patients could be cost-effective and convenient for patients especially those coming from remote areas.
机译：为了方便患者症状局部晚期非小细胞肺癌,尤其是到来从偏远地区我们雇用了两个缓和RT时间表。从医学研究理事会(MRC)随机研究2 x 8.5 Gy相隔一个星期,第二个(S2)是一个为期两天的RT安排:三个分数4.25 Gy和两个第一天分数4.25 Gy第二天。综述了记录92例(48 S1和44 S2)。两组结果相似;S1和S2的症状消失,60 24和20%,分别为:咳嗽咳血67%,胸痛和呼吸困难55 57和64%39总体条件改善了45%,36%,分别。分别在S1和S2:咳嗽70年和66年,胸痛咯血133年和139年,68年和62年呼吸困难74和69天。25周的S1和S2组(P = 0.89生存率较)。和7个(16%)病人还活着的S1分别和S2组。相应的数据是两个(4%)和两个S1和S2(4.7%)。根据这些报告文学对缓和的安全性和有效性hypofractionated放射治疗计划。在选定的病人可能是划算的方便患者尤其是到来从偏远地区。

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