In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions.

Koty PatrickP; Zhang Haifan; Franklin WilburAYousem SamuelALandreneau RodneyLevitt MarkL

首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions.

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In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions.

机译：体内p53、bcl - 2的表达及其作用在癌变前的和程序性细胞死亡恶性肺部病变。

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摘要

Forty-four specimens of non-malignant and malignant human lung tissue, taken from patients with non-small cell lung cancer (NSCLC), were examined for the expression of wild-type p53, mutant p53, and bcl-2 and the occurrence of programmed cell death (apoptosis). Wild-type p53 expression peaked in peritumoral and metaplastic samples, whereas mutant p53, bcl-2 and apoptosis were first detected in metaplasia and increased with progression to carcinoma. Bcl-2 positive samples had lower levels of apoptosis than bcl-2 negative samples and was independent of wild-type or mutant p53 expression. These results suggest that the over-expression of wild-type p53 may be an early cellular response to an alteration in normal cellular homeostasis. The ensuing increase in apoptosis appears to be relatively independent of mutant or wild-type p53 expression, but does not occur in cells expressing bcl-2.

机译：44的良性和标本恶性人类的肺组织,从病人与非小细胞肺癌(NSCLC)检查为野生型p53的表达,突变型p53、bcl - 2和发生程序性细胞死亡(凋亡)。表达在肿瘤前期达到顶峰,化生的样本,而突变型p53、bcl - 2和细胞凋亡第一次检测到化生和增加与发展为癌。样品比bcl - 2细胞凋亡水平较低负样本,并独立于野生型或突变型p53表达。野生型p53的表达一个早期的细胞反应的改变正常的细胞内稳态。在细胞凋亡似乎相对独立突变体和野生型p53表达,但是不是发生在细胞bcl - 2表达的。

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《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2002年第2期|155-163|共9页
作者
Koty PatrickP; Zhang Haifan; Franklin WilburAYousem SamuelALandreneau RodneyLevitt MarkL;
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Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238, USA.;

ath.uab.edu;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Gene Expression Regulation; Non-Small-Cell Lung Carcinoma; Small Cell Lung CarcinomaPrecancerous ConditionsMutantsbcl-2 GenesLOW LEVELMetaplasiaLung TissueCarcinoma;

机译：基因表达调控;非小细胞肺癌癌,小细胞肺癌CarcinomaPrecancerousConditionsMutantsbcl-2 GenesLOWLEVELMetaplasiaLung TissueCarcinoma;

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机译：Induction of Indoleamine 2,3-dioxygenase (IDO) Enzymatic activity Contributes to Interferon-Gamma Induced apoptosis and Death Receptor 5 Expression in Human Non-small Cell Lung Cancer Cells

In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions.

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