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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis.
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Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis.

机译：Sulfotransferase(饥饿)1 a1多态性肺癌易感性因素:病例对照分析。

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摘要

SULT1A1 enzyme is a member of the sulfotransferase family that alters biological activities of numerous carcinogenic and mutagenic compounds through sulfation. A genetic polymorphism in the coding region of SULT1A1 gene has been associated with modulated enzyme activity. There is a G-->A nucleotide polymorphism in SULT1A1 gene that codes for an Arg-->His substitution, which results in decreased activity and thermal stability of the SULT1A1 enzyme. Utilizing a case-control study design, we hypothesized that the variant allele of the SULT1A1 gene may be associated with lung cancer risk. The PCR-RFLP assay was used to successfully genotype the SULT1A1*2 allele (variant A-allele) in 463 Caucasian lung cancer cases and 485 frequency matched Caucasian controls. There was an overall significant difference between cases and controls when adjusted by sex and smoking status (adjusted OR=1.41, 95% CI: 1.04-1.91). The adjusted OR was higher for females (OR=1.64, 95% CI: 1.06-2.56) than for males (OR=1.23, 95% CI: 0.80-1.88). Furthermore, the risk was significantly higher in current smokers (OR=1.74, 95% CI: 1.08-2.29) and heavy smokers (OR=1.45, 95% CI: 1.05-2.00). Our results support the hypothesis that a genetic polymorphism in the SULT1A1 gene may be associated with increased lung cancer risk.
机译：SULT1A1酶是sulfotransferase的一员家庭改变生物的活动大量的致癌和致突变的化合物通过硫酸盐化作用。SULT1A1基因的编码区有关联调制酶活性。在SULT1A1基因核苷酸多态性编码一个参数——>替换,导致活动减少和热SULT1A1酶的稳定性。病例对照研究设计,我们假设SULT1A1基因的等位基因变体与肺癌相关的风险。分析被用来成功基因型SULT1A1 * 2等位基因(等位基因变体)在463年白种人的肺癌病例和485的频率与白人控制。显著区别情况下和控制当由性别和吸烟状况调整(调整或= 1.41,95% CI: 1.04—-1.91)。更高的女性(或= 1.64,95%置信区间CI: 1.06 - -2.56)比男性(或= 1.23,95% CI: 0.80—-1.88)。此外,风险更高吸烟者(或= 1.74,95% CI: 1.08—-2.29)重度吸烟者(或= 1.45,95% CI: 1.05—-2.00)。结果支持假设基因SULT1A1基因的多态性与肺癌发病风险增加。

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