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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis.
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The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis.

机译：粘附和信息粘附复杂和肺癌症入侵、转移和预后。

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Background: Lung cancer is the most common cause of cancer deaths in the western world. Progress in treatment results has been limited, and the prognosis is poor with a 5-year survival less than 15%. Based on new developments in molecular biology, our knowledge about lung carcinogenesis and mechanisms for invasion and metastasis has expanded and may in the future lead to more specific targeted therapies and better prognosis. The E-cadherin-catenin complex is critical for intercellular adhesiveness and maintenance of normal and malignant tissue architecture. Reduced expression of this complex in malignant disease is associated with tumour invasion, metastasis, and unfavorable prognosis. Methods: This review is based on search in the Medline database from 1991 to 2001. We have reviewed the relevance of the E-cadherin-catenin adhesion complex in malignancy in general and lung cancer in particular. Furthermore, its role as target for specific therapy is discussed. Results: Available data indicate that alterations of proteins involved in the E-cadherin-catenin complex are early incidents in cancer development. Reduced or altered expression of one or more of the components in this complex is associated with extended invasive and progressive behavior of cancer cells. Consistently, the E-cadherin-catenin complex appears to be increasingly delicate with regard to cancer prognosis. beta-Catenin, one of the components of the adhesion complex, also plays a significant role in cell signal transduction, gene activation, apoptosis inhibition, and increased cellular proliferation and migration. Conclusion: Inactivation of the E-cadherin-catenin adhesion complex, induced by genetic and epigenetic events, plays a significant role in multistage carcinogenesis, and seems to be associated with dedifferentiation, local invasion, regional metastasis, and reduced survival in lung cancer.
机译：背景:肺癌是最常见的原因西方世界的癌症死亡。治疗的结果是有限的,预后很差,5年存活率更少超过15%。生物学,我们了解肺部致癌作用和入侵和转移的机制并可能在未来导致更多的扩展特定的靶向治疗和预后更好。E-cadherin-catenin复杂是至关重要的在细胞间的粘聚性和维护正常和恶性组织架构。表达这种复杂的恶性疾病与肿瘤侵袭、转移和不利的预后。是基于在Medline数据库中搜索的1991年到2001年。E-cadherin-catenin粘附复杂恶性肿瘤通常和肺癌特定的。具体的治疗进行了探讨。数据显示,变化的蛋白质参与E-cadherin-catenin复杂早期的事件在癌症的发展。改变一个或多个的表情在这个复杂的与组件扩展的侵入性和进步的行为癌细胞。似乎E-cadherin-catenin复杂越来越精致的关于癌症预后。粘附复杂,也是一个重要的作用在细胞信号转导、基因激活、细胞凋亡抑制和增加细胞增殖和迁移。失活的E-cadherin-catenin附着力复杂的遗传和表观遗传引起的在多级事件中起着重要的作用致癌作用,似乎是相关联的去分化、本地入侵区域转移,降低肺癌的生存。

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