Defected expression of E-cadherin in non-small cell lung cancer.

Fei Q; Zhang H; Chen XWang JCZhang RXu WZhang ZZou WZhang KQi QWang MTao SLuo Z

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Defected expression of E-cadherin in non-small cell lung cancer.

机译：非小叛逃钙粘蛋白的表达细胞肺癌。

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Reduced expression of E-cadherin, a cell-cell adhesion molecule, was frequently observed in several types of human carcinomas, and the protein plays a role as an invasion suppressor in vitro. In an attempt to evaluate the significance of E-cadherin gene in non-small cell lung cancer (NSCLC), we undertook the immunohistochemical and molecule structural analyses of E-cadherin gene in 40 resection specimens of NSCLC and the corresponding paracarcinoma controls. E-cadherin expression was explored by immunohistochemistry with a monoclonal antibody, and the E-cadherin gene was studied by polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP). The analysis represented in this study demonstrated clear reduction in the expression of E-cadherin proteins in the cancer tissues. However, only in one amplicon were aberrant bands detected, which was a single polymorphic site (codon 692; exon 13), and no somatic mutation was found. These results indicated that defected E-cadherin expression might play a role in the development of malignant phenotype in NSCLC, even though the genetic mutation of E-cadherin gene is not involved in the pathogenesis of NSCLC and does not appear to be direct cause for the reduced expression of E-cadherin gene.

机译：减少钙粘蛋白的表达,一个信息粘附分子,经常被观察到几种类型的人类癌,蛋白质作为抑制入侵中发挥作用体外。钙粘蛋白基因在非小细胞肺癌(NSCLC),我们进行了免疫组织化学和钙粘蛋白基因的分子结构分析在40切除标本的非小细胞肺癌和相应paracarcinoma控制。表达式被免疫组织化学研究用单克隆抗体和粘附基因通过聚合酶链反应进行了研究单链构象多态性分析(PCR-SSCP)。研究展示了明显的减少钙粘蛋白的表达在癌症组织。异常检测到乐队,这是一个单身多态的网站(密码子692;体细胞突变被发现。表明叛逃钙粘蛋白的表达可能在恶性的发展发挥作用表型在非小细胞肺癌,即使遗传钙粘蛋白基因的突变是没有参与非小细胞肺癌的发病机制并没有出现是表达减少的直接原因钙粘蛋白基因。

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来源
《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2002年第2期|147-152|共6页
作者
Fei Q; Zhang H; Chen XWang JCZhang RXu WZhang ZZou WZhang KQi QWang MTao SLuo Z;
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作者单位

Laboratory of Population and Quantitative Genetics, Institute of Genetics, Fudan University, 200433, Shanghai, PR China;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Non-Small-Cell Lung Carcinoma; Cadherins; Single Person;

机译：非小细胞肺癌;钙粘着蛋白;单身人;

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3. Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱 [J] . Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第18期

机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱
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机译：Induction of Indoleamine 2,3-dioxygenase (IDO) Enzymatic activity Contributes to Interferon-Gamma Induced apoptosis and Death Receptor 5 Expression in Human Non-small Cell Lung Cancer Cells

Defected expression of E-cadherin in non-small cell lung cancer.

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