Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.

Howell BW; Gertler FB; Cooper JA

首页> 外文期刊>EMBO Journal >Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.

【24h】

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.

机译：禁用鼠标(mDab1): Src结合蛋白与神经发展。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Here, we identify a mouse homolog of the Drosophila Disabled (Dab) protein, mDab1, and show it is an adaptor molecule functioning in neural development. We find that mDab1 is expressed in certain neuronal and hematopoietic cell lines, and is localized to the growing nerves of embryonic mice. During mouse embryogenesis, mDab1 is tyrosine phosphorylated when the nervous system is undergoing dramatic expansion. However, when nerve tracts are established, mDab1 lacks detectable phosphotyrosine. Tyrosine-phosphorylated mDab1 associates with the SH2 domains of Src, Fyn and Abl. An interaction between mDab1 and Src is observed when P19 embryonal carcinoma (EC) cells undergo differentiation into neuronal cell types. mDab1 can also form complexes with cellular phosphotyrosyl proteins through a domain that is related to the phosphotyrosine binding (PTB) domains of the Shc family of adaptor proteins. The mDab1 PTB domain binds to phosphotyrosine-containing proteins of 200, 120 and 40 kDa from extracts of embryonic mouse heads. The properties of mDab1 and genetic analysis of Dab in Drosophila suggest that these molecules function in key signal transduction pathways involved in the formation of neural networks.

机译：在这里,我们确定一个鼠标的相同器官果蝇残疾(Dab)蛋白质、mDab1和显示它是一个衔接分子功能神经发展。表示在某些神经和造血细胞系,是日益增长的本地化胚胎小鼠的神经。胚胎发生,mDab1酪氨酸磷酸化当神经系统正在经历戏剧性扩张。建立,mDab1缺乏检测phosphotyrosine。同事的SH2域Src,菲英岛和Abl。观察到当P19胚胎性癌(EC)细胞经历分化为神经细胞。mDab1与细胞也可以形成复合物通过域phosphotyrosyl蛋白质有关phosphotyrosine绑定(PTB)人体自燃现象领域的适配器蛋白质的家庭。mDab1 PTB域结合200年phosphotyrosine-containing蛋白质,120和40 kDa胚胎提取的老鼠正面。民建联在果蝇表明这些分析信号转导分子功能的关键通路参与神经的形成网络。

著录项

来源
《EMBO Journal》 |1997年第1期|121-132|共12页
作者
Howell BW; Gertler FB; Cooper JA;
展开▼
作者单位

Fred Hutchinson Cancer Research Center Seattle, WA 98104, USA.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类分子生物学;分子生物学;
关键词
SH2 Domain; Signal Transduction Pathways; fusion proteinsrecombinant fusion proteinsNerve Tissue ProteinsNeural PathwayNeurogenesisShc Signaling Adaptor ProteinsphosphotyrosineAudio recordingsrc Homology DomainsNervous SystemPTB DomainDisabled PersonsDrosophila;

机译：SH2域;信号转导途径;融合proteinsrecombinant融合proteinsNerve组织ProteinsNeural PathwayNeurogenesisShc信号适配器ProteinsphosphotyrosineAudio recordingsrc同源性DomainsNervous SystemPTB DomainDisabled;

相似文献

外文文献
中文文献
专利

1. Effects of serum containing natural cerebrolysin on glucose-regulated protein 78 and CCAAT enhancer-binding protein homologous protein expression in neuronal PC12 cells following tunicamycin-induced endoplasmic reticulum stress [J] . Zhengzhi Wu, Ming Li, Andrew C.J. HuangO, 中国神经再生研究（英文版） . 2009,第002期
2. Considering calcium-binding proteins in invertebrates: multi-functional proteins that shape neuronal growth [J] . Charles R.Tessier 中国神经再生研究（英文版） . 2016,第002期
3. Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatogenic function in mouse testes [J] . Zhi-Ping Xia, Xin-Min Zheng, Hang Zheng, 亚洲男性学杂志（英文版） . 2012,第006期
4. Effects of basic fibroblast growth factor on hippocampal and parietal cortical neuronal cAMP-response element-binding protein expression in a rat model of focal cerebral ischemia/reperfusion [J] . Chunyu Qu, Xuesong Xing, Jin Zang 中国神经再生研究（英文版） . 2009,第009期
5. Effects of basic fibroblast growth factor on hippocampal and parietal cortical neuronal cAMP-response element-binding protein expression in a rat model of focal cerebral ischemia/reperfusion [J] . Chunyu Qu, Xuesong Xing, Jin Zang 中国神经再生研究：英文版 . 2009,第009期
6. SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 2 controls floral organ development and plant fertility by activating ASYMMETRIC LEAVES 2 in Arabidopsis thaliana [J] . Wang Zhishuo, Wang Ying, Kohalmi Susanne E., Plant Molecular Biology . 2016,第6期

机译：SQUAMOSA PROTOTER BINDING PROTEIN-LIKE 2通过激活拟南芥中的非对称叶2来控制花器官发育和植物育性。
7. Impact of serum Wisteria floribunda agglutinin positive Mac-2-binding protein and serum interferon-gamma-inducible protein-10 in primary biliary cirrhosis [J] . Nishikawa Hiroki, Enomoto Hirayuki, Iwata YoshinoriHasegawa KunihiroNakano ChikageTakata RyoNishimura TakashiYoh KazunoriAizawa NobuhiroSakai YoshiyukiIkeda NaotoTakashima TomoyukiIshii AkioIijima HirokoNishiguchi Shuhei Hepatology research: the official journal of the Japan Society of Hepatology . 2016,第6期

机译：紫藤多花植物的影响血清凝集素积极Mac-2-binding蛋白质和血清interferon-gamma-inducible protein-10在初级胆汁性肝硬化
8. ABI5-BINDING PROTEIN2 Coordinates CONSTANS to Delay Flowering by Recruiting the Transcriptional Corepressor TPR2 [O] . Guanxiao Chang, Wenjuan Yang, Qili Zhang, 2019

机译：ABI5-BINDING PROTEIN2协调CONSTANS通过招募转录共表达抑制剂TPR2延迟开花。
9. A mass spectrometry based direct-binding assay for screening binding partners of proteins [O] . Zou HF, Zhang QC, Guo Z, 2002

机译：a mass spectrometry based direct-binding assay for screening binding partners of proteins

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.

摘要

著录项

相似文献

相关主题

期刊订阅