Gemcitabine (Gemzar)-based induction chemotherapy in non-small-cell lung cancer.

Scagliotti GV; Novello S

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Gemcitabine (Gemzar)-based induction chemotherapy in non-small-cell lung cancer.

机译：吉西他滨(吉)的诱导化疗在非小细胞肺癌。

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The gemcitabine/cisplatin combination is a key regimen in unresectable locally advanced and metastatic non-small-cell lung cancer (NSCLC), and, consequently, it is a logical step forward to investigate the activity of this new combination in less advanced stages of NSCLC. Efficacy data of several phase II studies performed in a mixed study population of stage IIIA and IIIB disease investigating gemcitabine/cisplatin as induction treatment indicate an average response rate > 60%. The treatment is rather well tolerated and toxicity is especially mild when a 3-week schedule is used. More recently, five randomized studies, one already completed, have been designed to investigate the role of induction chemotherapy in early stage (I and II) NSCLC. In Italy, an ongoing randomized clinical trial called Chemotherapy for Early Stages Trial (ChEST) compares the efficacy of surgery alone or surgery plus induction gemcitabine/cisplatin in operable patients (T2-3N0, T1-2N1, T3N1) having progression-free survival as a primary end point.

机译：吉西他滨/顺铂联合是一个关键方案在不可切除的局部晚期和转移性非小细胞肺癌(NSCLC),因此,这是一个合乎逻辑的步骤这个新的调查活动结合在晚期非小细胞肺癌。功效二期的一些研究的数据表现在混合研究人口的阶段iii a和希望疾病调查吉西他滨/顺铂诱导治疗显示平均响应率> 60%。治疗,而良好的耐受性和毒性特别温和的抓捕计划是什么时候吗使用。已经完成,设计诱导化疗的作用进行调查早期非小细胞肺癌(I和II)。正在进行的随机临床试验化疗早期阶段试验(胸部)比较手术单独或手术的疗效+感应吉西他滨/顺铂在可操作的病人(T2-3N0 T1-2N1 T3N1)无进展生存作为主要终点。

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来源
《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2002年第2期|S13-19|共7页
作者
Scagliotti GV; Novello S;
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作者单位

Thoracic Oncology Unit, Department of Clinical and Biological Sciences, S Luigi Hospital, University of Torino, Orbassano, Turin, Italy. scagliotti@ihnet.it;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Non-Small-Cell Lung Carcinoma; Antineoplastic Agents; AntimetabolitesLung Cancernew combinationInduction ChemotherapyAntineoplastic Combined Chemotherapy Protocols;

机译：非小细胞肺癌;抗肿瘤药代理;AntimetabolitesLung CancernewcombinationInduction ChemotherapyAntineoplastic联合化疗方案;

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机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱
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Gemcitabine (Gemzar)-based induction chemotherapy in non-small-cell lung cancer.

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