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首页> 外文期刊>EMBO Journal >MAT1, CDK7 AND CYCLIN H FORM A KINASE COMPLEX WHICH IS UV LIGHT-SENSITIVE UPON ASSOCIATION WITH TFIIH
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MAT1, CDK7 AND CYCLIN H FORM A KINASE COMPLEX WHICH IS UV LIGHT-SENSITIVE UPON ASSOCIATION WITH TFIIH

机译：MAT1, CDK7和细胞周期蛋白激酶复杂形式这是紫外线感光联系

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摘要

MAT1, cyclin H and cdk7 are part of TFIIH, a class II transcription factor which possesses numerous subunits of which several have been shown to be involved in processes other than transcription. Two of them, XPD (ERCC2) and XPB (ERCC3), are helicases involved in nucleotide excision repair (NER), whereas cdk7, cyclin H and MAT1 are thought to participate in cell cycle regulation. MAT1, cyclin H and cdk7 exist as a ternary complex either free or associated with TFIIH from which the latter can be dissociated at high salt concentration. MAT1 is strongly associated with cdk7 and cyclin H. Although not strictly required for the formation and activity of the complex, it stimulates its kinase activity. The kinase activity of TFIIH, which is constant during the cell cycle, is reduced after UV light irradiation.
机译：MAT1,细胞周期蛋白H和cdk7 TFIIH的一部分,一个类二世拥有众多转录因子子单元的一些已经被证明参与过程除了转录。他们两个,XPD (ERCC2)和XPB (ERCC3)解旋酶参与核苷酸切除修复(尼珥),而cdk7,细胞周期蛋白H和MAT1参与细胞周期调控。MAT1,细胞周期蛋白H和cdk7存在三元复杂的自由或与TFIIH从有关后者可以在高盐分离浓度。cdk7和细胞周期蛋白h .虽然没有严格的要求的形成和活动复杂,刺激其激酶活性。TFIIH活动,这期间是常数细胞周期,减少紫外线辐照。

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