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首页> 外文期刊>Catalysis science & technology >Ni-Catalysed Intramolecular [4+4]-cycloadditions of bis-dienes towards eight-membered fused bicyclic systems: a combined experimental and computational study
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Ni-Catalysed Intramolecular [4+4]-cycloadditions of bis-dienes towards eight-membered fused bicyclic systems: a combined experimental and computational study

机译：Ni-Catalysed分子内(4 + 4)环加bis-dienes对8人融合双环系统:结合实验和计算研究

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摘要

Detailed investigations on the use of nickel(0)-based catalysts for intramolecular [4+4]-cycloadditions are presented. Nickel(0) complexes derived from electron-rich triarylphosphines proved to be efficient catalysts for intramolecular [4+4]-cycloadditions of an array of structurally diverse bis-dienes (10 examples, up to 78% isolated yield). The reported synthetic methodology leads to cis-eight-membered fused [6.3.0] bicyclic compounds as well as trans- or cis-eight-membered fused [6.4.0] bicyclic systems. Computational studies on the stereo-determining step of the reaction in combination with experimental results demonstrated that the stereochemical outcome is dictated by the length of the chain linking the two diene units and the geometry of the C?C double bonds of the substrates.
机译：详细调查的使用镍(0)的分子内的催化剂(4 + 4)环加。复合物来自富triarylphosphines被证明是有效的催化剂分子内(4 + 4)环加一个数组的结构多样化bis-dienes(10例,孤立的收益率高达78%)。报道合成方法导致cis-eight-membered融合6.3.0二环化合物以及反式或cis-eight-membered融合6.4.0双环系统。研究的stereo-determining一步结合实验结果的反应证明了立体化学的结果由链式连接的长度两个二烯单元的几何C ?双键的基质。

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