• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Protocols in Nucleic Acid Chemistry >Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides
【24h】

Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides

机译：高效的Trifluoromethylated嘌呤合成核糖核苷和核苷酸

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The protocols presented in this article describe highly detailed synthesis of trifluoromethylated purine nucleotides and nucleosides (G and A). The procedure involves trifluoromethylation of properly protected (acetylated) nucleosides, followed by deprotection leading to key CF3-containing nucleosides. This gives synthetic access to 8-CF3-substituted guanosine derivatives and three adenosine derivatives (8-CF3, 2-CF3, and 2,8-diCF3). In further steps, phosphorylation and phosphate elongation (for selected examples) result in respective tri-fluoromethylated nucleoside mono-, di-, and triphosphates. Support protocols are included for compound handling, purification procedures, analytical sample preparation, and analytical techniques used throughout the performance of the basic protocols.
机译：本文描述的协议高度详细的trifluoromethylated合成嘌呤核苷酸和核苷(G, A)过程包括trifluoromethylation妥善保护(乙酰化)核苷,其次是去领导的关键CF3-containing核苷。访问8-CF3-substituted鸟苷衍生品和三个腺苷衍生物(8-CF3 2-CF3,2、8-diCF3)。和磷酸盐伸长(用于选定的例子)导致各自tri-fluoromethylated核苷mono - di -和三磷酸腺苷。协议包括复合处理,净化过程,分析样本准备和分析技术在基本的性能协议。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号